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Medicine for preventing and treating diabets and kidney disease and preparing method

A technology of diabetic nephropathy and medicine, which is applied in the field of medicine for preventing and treating diabetic nephropathy, and can solve problems such as death and death of diabetic patients

Inactive Publication Date: 2007-08-29
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are many clinical drugs that can effectively control the blood sugar level of diabetic patients, most diabetic patients die from related complications, especially cardiovascular and renal complications have become the main cause of death in diabetic patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 The composition of breviscapine and rhubarb is prepared into tablets

[0018] About 7,000 grams of the whole plant of Eeigeron breviscapus (Vant Hand-Mazz) (also known as Short Pavilion Flycap) is used, and according to the current conventional extraction method of breviscapus, such as using 75% ethanol to reflux and extract twice (5 times the volume of ethanol for the first time, 3 times the volume of ethanol for the second time, 1 hour each time), the extract recovers ethanol, concentrates, adjusts the pH to 6.5 with NaOH and dissolves, filters, and the filtrate is washed with H 2 SO 4 Adjust the pH to 2.0, precipitate breviscapine, and refine to obtain 100 grams of 4',5,6-trihydroxyflavone-7-O-glucuronide (breviscapine).

[0019] Submerge 2 kg of rhubarb plus 5 times the volume of rhubarb in water, boil for 1 hour, and filter; extract the filter residue once more with 3 times the volume of water for 1 hour, combine the two extracts, and concentrate to the ...

Embodiment 2

[0021] Example 2 The extraction method is the same as in Example 1, the weight ratio of breviscapine: rhubarb extract is 1:0.3, and the granules are prepared according to the conventional preparation method.

Embodiment 3

[0022] The extraction method of Example 3 is the same as that of Example 1, the weight ratio of scutellarin: rhubarb extract is 1:15, and capsules are prepared according to conventional preparation methods.

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PUM

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Abstract

The present invention relates to a medicine for preventing and curing diabetes and nephroses and its preparation method. Said medicine is made up by using breviscapine and rhubarb through conventional preparation process.

Description

【Technical field】 [0001] The invention relates to a medicine for preventing and treating diabetic nephropathy, and also relates to a preparation method of the medicine. 【Background technique】 [0002] Epidemiological surveys show that the standardized prevalence rate of diabetes in my country is 3.21%, that is to say, there are more than 50 million diabetic patients in my country at present, and the incidence of diabetes is increasing year by year. Among these diabetic (DM) patients, approximately One third will develop diabetic nephropathy (DN). In the United States, DN has risen to become the first cause of end-stage renal disease (ESRD), accounting for about 38%, accounting for 7.9% in Europe, and as high as 28% in Japan. In my country, DN accounts for about 6-10% of the total number of ESRD. The proportion of DN patients in dialysis patients is increasing day by day. At present, although there are many clinical drugs that can effectively control the blood sugar level of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K31/7048A61K36/28A61P3/10A61P13/12
Inventor 朱邦豪
Owner SUN YAT SEN UNIV