132 results about "Diabetic renal disease" patented technology

The diabetes treating and nephrosis medicine is prepared with 7 kinds of Chinese medicinal materials including astragalus root, sealwort, dogwood, leech, Chuanxiong rhizome, etc. The preparation process is also disclosed. The medicine of the present invention has the functions of benefiting vital energy, promoting blood circulation, nourishing Yin and kidney, and is suitable for treating diabetes caused by deficient vital energy and Yin and meridian stasis and nephrosis. Clinical application shows that it has fast and obvious treating effect and no bad reaction.

A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The subject has type 2 diabetes; renal hypertrophy or hyperplasia associated with diabetic nephropathy; Tay-Sachs; Gaucher's; or Fabry's disease. Methods of decreasing plasma TNF-α, lowering blood glucose levels, decreasing glycated hemoglobin levels, inhibiting glucosylceramide synthase, and lowering glycosphingolipid concentrations in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

The invention discloses a medicine composition for treating diabetic nephropathy. The prepared medicine composition comprises the following main medicine effect raw materials in parts by weight: 300 to 400 parts of astragalus mongholicus, 200 to 300 parts of prepared rehmannia root, 100 to 200 parts of dogwood, 200 to 300 parts of salvia miltiorrhiza, 50 to 150 parts of monkshood, 200 to 300 parts of poria cocos, 50 to 150 parts of Chinese yam, 100 to 200 parts of ligusticum wallichii, 100 to 200 parts of angelica sinensis, 50 to 150 parts of curcuma zedoary and 200 to 300 parts of leonurus. A preparation method of the medicine composition comprises the steps that: all medicine effect raw materials are weighed according to the recipe and are uniformly mixed through pulverization, water extraction concentration or a pulverization and water extraction concentration combination mode, and the medicine composition is prepared. The medicine composition disclosed by the invention can warm the kidney, strengthen the spleen, activate the blood and promote the diuresis, and is used for patients in the clinical stage of the diabetic nephropathy and patients with the symptoms of deep thready pulse, white fur, dark tongue nature, slight face and double lower limb edema, anorexia and loose stool, sallow complexion or paleness, no luster, dizziness insomnia and lassitude caused by spleen andkidney deficiency and collaterals stasis resistance.

The invention provides a diabetic nephropathy-non-diabetic nephropathy differential diagnosis device and relates to the biological detection technology field. Defects that a standard in a traditionalchronic kidney disease clinical practice guide (KDOQI) is not objective and unified and is not suitable for serving as a diagnosis standard, and a traditional kidney puncture biopsy technology is large in trauma, can cause complications after operation and is high in technical difficulty. In a diabetic nephropathy-non-diabetic nephropathy differential diagnosis process provided in the invention, anew index is selected by adopting a machine learning method to construct a diabetic nephropathy and non-diabetic nephropathy differential diagnosis model, pain of a patient can be reduced, a diagnosis result is accurate, an application range is wide, and a good auxiliary diagnosis effect is provided for clinical practice.

The invention provides a traditional Chinese medicine composition for treating diabetic nephropathy. The traditional Chinese medicine composition comprises the following components of Ramulus euonymi, trichosanthes root, Panax pseudo-ginseng var. notoginseng and rhizoma coptidis according to the proportion by weight of 1-3:1-2:1-2:1-3. When being taken, the four medicines are respectively smashed and mixed, decocted by a traditional Chinese medicine decocting method and filtered, and the filtered liquid medicine is taken.

The invention provides an application of a Aspidopterys obcordata Hemsl. extract in preparation of a medicine for preventing and / or treating diabetic nephropathy. The medicine for preventing and / or treating diabetic nephropathy provided by the invention takes the Aspidopterys obcordata Hemsl. extract as an active component, and the medicine can be prepared into any dosage form together with pharmaceutically common auxiliary materials. The Aspidopterys obcordata Hemsl. extract can relieve kidney injury and inhibit proliferation of fibroblasts at a high glucose level, has the effect of resisting renal interstitial fibrosis, has no obvious cytotoxicity to normal tissue cells, and has good application prospect in treatment of diabetic nephropathy.

The invention relates to the application of cornuside in preparing pharmaceuticals used for curing diabetic nephropathy. The invention raises a novel application of cornuside in preparing pharmaceuticals used to cure diabetic nephropathy and provides a novel pharmaceutical choice for curing diabetic nephropathy. Through experimental verification, 0.1g-5.5g / kg dosage of cornuside has remarkable effects in curing diabetic nephropathy. Cornuside has satisfying effects of anti-inflammatory damage and improving renal function on renal tissue under the condition of diabetes, and is effective pharmaceutical in curing diabetic nephropathy.

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

The invention discloses a significant position extracted from hydrangea paniculata sieb and the method for producing it, medical compounds containing such position, and the usage of it, especially in producing drugs for preventing and / or curing kidney incompetence, high blood pressure and diabetes, kidney disease.

The invention discloses a detection kit and a detection method for diabetic kidney diseases. The detection kit comprises a plate sealing film; a sealing the bag; an enzyme-labeled coating plate; a standard substance: 2700 ng / L; a standard substance diluent; an enzyme-labeled reagent; a sample diluent; a color developing agent solution A; a color developing agent solution B; a stop solution; and aconcentrated washing liquid. The invention relates to the technical field of diabetic nephropathy detection. The detection method is simple to operate, is less affected by metabolic disorders and hemodynamics, can detect diabetic nephropathy in the I phase, has extremely high sensitivity, and has great significance for clinical early diagnosis and discovery of diabetes.

The invention discloses application of carnosic acid and rosemary acid to jointly prepare a drug for prevention and treatment of type II diabetes nephropathy. According to the application, it is foundthat the carnosic acid and the rosemary acid with the quality ratio of 6:1 can significantly and synergistically reduce fasting blood glucose of a type II diabetic nephropathy mouse, can significantly and synergistically decrease the urinary protein excretion rate and increase the urinary creatinine content and has significant and synergetic improvement effect on the kidney function of the diabetes nephropathy mouse, and the synergetic effect is unexpected by the technicians in the field.

A problem of the present invention is to provide an agent which allows effective protection of cardiac damage in a case where a variety of symptoms such as arrhythmia, cardiac desmoplasia and heart-failure are likely to accompany with hypertension, hypercardia, myocardial infarction, arteriosclerosis, diabetic and non-diabetic renal diseases, and re-stenosis posterior to PTCA. The agent contains an effective amount of at least one protease inhibitor to administer intravenously or orally. The protease inhibitor is preferably a serine protease inhibitor. The serine protease inhibitor is preferably a chymotrypsin-like serine protease inhibitor. Concretely, it is a chymase inhibitor such as a peptide derivative of aryl diester of alpha-aminoalkylphosphonic acid which is Suc-Val-Pro-PheP(OPh)2, and preferably the enantiormer Suc-Val-Pro-L-PheP(OPh)2.

The invention relates to a traditional Chinese medicine for treating IV stage diabetic nephropathies, and can effectively solve the problem of therapeutic medication of the IV stage diabetic nephropathies. According to the technical scheme for solving the problem, the traditional Chinese medicine is prepared from 30g-60g of herba agrimoniae, 15g-30g of cortex cinnamomi, 10g-20g of raw rhizoma atractylodis macrocephalae, 10g-20g of semen allii tuberose, 10g-20g of folium microcotis, 10g-20g of flos gossampini, 10g-20g of herba saururi chinensis and 5g-10g of raw licorice roots; after the components are mixed, drinking water 10 times the weight of the mixed raw materials is added to soak the mixed raw materials for 30 minutes, mixed raw materials are decocted with a strong fire, and then, are decocted with a mild fire for 30 minutes, and filtering is performed to obtain a first-time filtrate; then, the drinking water 8 times the weight of the mixed raw materials is added into herb residues, the herb residues are decocted with the strong fire, and then, are decocted with the mild fire for 25 minutes, and filtering is performed to obtain second-time filtrate; and the first-time filtrate and the second-time filtrate are combined, and the combined filtrate is decocted with a medium fire to make the combined filtrate concentrated to 300-500 mL. The traditional Chinese medicine has theadvantages that the raw materials are abundant, and the traditional Chinese medicine has scientific and reasonable matching, is easy to produce and prepare, convenient to take, has a good effect, haseffects of reinforcing qi and warming yang and promoting dieresis and clearing heat, can effectively treat the IV stage diabetic nephropathies, and has enormous economic and social benefits.