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Pharmaceutical composition and its application in preparation of medicine for treating type II diabetes

A composition and drug technology, applied in drug combinations, metabolic diseases, pharmaceutical formulations, etc., can solve the problems of islet β-cell failure, increased dosage, complications, etc., to reduce renal function and structural damage, reduce Side effects, the effect of reducing side effects

Inactive Publication Date: 2006-04-26
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although gliquidone has made significant progress compared with the first-generation sulfonylurea drugs, with the prolongation of medication time, the sensitivity of the islet β cell membrane receptors to it decreases, drug resistance will develop, and it is easy to cause insulin overdose. islet β-cell failure, resulting in secondary failure
At this time, it is necessary to increase the dosage or switch to other hypoglycemic drugs, and increasing the dosage often leads to the increase of side effects and the occurrence or aggravation of complications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The combination product was used to treat diabetes with gliquidone alone to carry out a clinical comparison test:

[0048] 1. The patient selection criteria are as follows: all diabetic patients meet the 1997 ADA / 1985 WHO diabetes diagnostic criteria, and 18 diabetic nephropathy (DN) patients are selected to match the urine protein, renal function and the development speed of renal function damage within one year There were no significant differences in gender (half male and half male), age, duration of diabetes, urine protein, blood urea nitrogen (BUN) and glycated hemoglobin (HbAlc) between the two groups of patients (P>0.05) (see Table 1).

[0049] group

example

number

age

duration of diabetes

(year)

Urinary protein (g / L)

BUN

(mmol / L)

HbAlc(%)

control

Group

8

54±

6.7

10.3±7.1

6.2±2.5

9.5±0.7

6.5±1.2

treat

Group

...

Embodiment 2

[0072] Preparation of tablets:

[0073] With the pharmaceutical composition containing 15g of gliquidone, sodium taurate 1058g (equivalent to 900g of taurine), add compressible starch 100g, dextrin 25g, microcrystalline cellulose 5g, magnesium stearate 2.5g, Mix evenly, granulate with 40% ethanol, press into tablets to make 1000 tablets, and coat with film.

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PUM

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Abstract

The invention relates a medicinal composition containing Gliquidone, taurine and its medicinal salts, and the use of the composition in preparing medicament for the treatment of diabetes, the treatment and / or prevention of renal disease complication related to type II diabetes. The composition comprises Gliquidone 10-180mg, taurine and its medicinal salts 0.5-10g, and pharmaceutically acceptable carrying agents.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition for treating diabetes, more specifically, a kind of pharmaceutical composition containing gliquidone and taurine, and this composition is used for treating II diabetes, treatment and / or prevention Use in combination drugs for renal complications associated with type II diabetes. Background technique [0002] Type II diabetes is a group of metabolic diseases mainly characterized by hyperglycemia due to defects in insulin secretion and decreased biological effects of insulin caused by genetic defects and acquired environmental factors. Diabetes is the most harmful to human health because of various chronic complications based on arteriosclerosis and microvascular disease, such as diabetic nephropathy, diabetic heart disease, diabetic extremity gangrene, diabetic cerebrovascular disease, diabetic retinopathy and neuropathy, etc. Therefore, it often causes great pain to patients. At p...

Claims

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Application Information

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IPC IPC(8): A61K31/4704A61K31/185A61P3/10
Inventor 王春龙刘衡汤立达
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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