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Korean drug extract for preventing and treating diabetic nephropathy and preparation method and application thereof

A technology of diabetic nephropathy and medicine extract, which is applied in the medicine extract and its preparation, medicine tablet and application field for preventing and treating diabetic nephropathy. The effect of increasing the content of substances, improving the therapeutic effect and reducing the rate of ointment

Active Publication Date: 2018-11-06
延吉朝耀生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to further solve the problem that the existing Korean medicine compound extract has a large dosage and is not easy to carry, the present invention provides a drug for preventing and treating DKD. Mouse albumin, NAG and BUN content

Method used

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  • Korean drug extract for preventing and treating diabetic nephropathy and preparation method and application thereof
  • Korean drug extract for preventing and treating diabetic nephropathy and preparation method and application thereof
  • Korean drug extract for preventing and treating diabetic nephropathy and preparation method and application thereof

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preparation example Construction

[0045] The present invention provides a preparation method of the Korean medicine extract for preventing and treating DKD described in the technical scheme, comprising the following steps:

[0046] (1) extracting the raw material of the medicine extract by using ethanol aqueous solution with a mass fraction of 20-40% as a solvent, collecting the liquid part, and obtaining the extract;

[0047] In parts by weight, the raw materials of the Korean medicine extract include 2-4 parts of kudzu root, 2-4 parts of scutellaria baicalensis, 2-4 parts of yam, 2-4 parts of wormwood, 1-2 parts of schisandra, and 1-2 parts of bellflower , 1-2 parts of Cimicifuga, 1-2 parts of Angelica dahurica and 1-2 parts of Ophiopogon japonicus;

[0048] (2) The adsorption clarification method adsorbs the extract, collects the liquid part, and obtains a refined solution;

[0049] (3) Purify the refined liquid with a D101 type macroporous resin column, collect the eluate, and dry to obtain the extract of t...

Embodiment 1

[0113] (1) Take the raw materials of the Korean medicine extract: Pueraria 20g, Scutellaria baicalensis 20g, Chinese yam 20g, Ligusticum edulis 20g, Schisandra 10g, Bellflower 10g, Cimicifuga 10g, Angelica dahurica 10g, Ophiopogon japonicus 10g. Mix a total of 130 g of the above raw materials with 1.3 kg of 30% ethanol aqueous solution by mass fraction, soak for 1.5 hours, and filter to obtain the filtrate and filter residue for the first time; take the filter residue and add 8 times the mass fraction of 30% ethanol aqueous solution to mix, and extract for 1 hour , and filtered to obtain the second filtrate and filter residue; combine the filtrates extracted twice to obtain the extract.

[0114] (2) Concentrate the extract to 130g to obtain a concentrated extract, add the concentrated extract at 60°C to the ZTC 1+1 natural clarifier B component with a volume of 7% of the concentrated extract, mix and stir, Refrigerate and stand for 24 hours, take the liquid part after standing...

Embodiment 2

[0119] (1) Take the raw materials of the Korean medicine extract: Pueraria 18g, Scutellaria baicalensis 21g, Chinese yam 20g, Ligusticum edulis 20g, Schisandra 10g, Bellflower 11g, Cimicifuga 10g, Angelica dahurica 10g, Ophiopogon japonicus 9g. A total of 129 g of the above raw materials were mixed with 1.5 kg of 28% ethanol aqueous solution by mass fraction, soaked for 1 hour, and filtered to obtain a filtrate and an extract.

[0120] (2) Concentrate the extract to 129g to obtain a concentrated extract, add the concentrated extract at 60°C to the ZTC 1+1 natural clarifier B component with a volume of 7% of the concentrated extract, mix and stir, Refrigerate and stand for 24 hours, take the liquid part after standing, centrifuge, filter and take the filtrate, mix the filtrate with component A which is half the volume of component B, filter after standing for 4 hours, take the liquid part, and obtain the refined solution.

[0121] (3) Soak a sufficient amount of D101-type MAR i...

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Abstract

The invention relates to the field of a drug, and provides a preparation method of a Korean drug extract for preventing and treating diabetic nephropathy. The method comprises the following steps: ethanol extraction, refining by an adsorption clarification method and purifying with a macroporous resin column. Compared with the prior art, by limiting the elution condition, the effective substance content proportion in the Korean drug extract is adjusted, the flavonoid substance content such as monarch drug component Puerarin is obviously increased, and the treatment effect of the Korean drug extract is increased. The invention provides the Korean drug extract obtained by the above preparation method, and the mass ratio of general flavone, total polysaccharide and total saponin in the Koreandrug extract is 5-15:1-3:1-4. The active ingredient ratio in the Korean drug extract is reasonable, and the blood sugar reduction and kidney protection effects are obvious. The Korean drug tablets containing the Korean drug extract has the advantages of small administration amount and convenient carrying. The Korean drug extract or the Korean drug tablets can be used as the drug for preventing and treating diabetic nephropathy.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an extract of a medicine for preventing and treating diabetic nephropathy and a preparation method thereof, a tablet containing the extract of a medicine for medicine and its application. Background technique [0002] Diabetic kidney disease (Diabetic kidney disease, DKD) refers to the kidney disease caused by diabetes mellitus (DM), which is the most harmful chronic complication caused by DM. The main clinical manifestation of DKD is proteinuria. DKD is the number one factor leading to end-stage renal failure. Once renal fibrosis enters the middle and late stages, the kidney damage will be irreversible, and eventually end-stage renal failure (End Stage Renal Disease, ESRD) may develop. In the early stage of kidney disease in DKD, hypertrophy of the kidneys can be seen, and the cortex is thickened and pale. If timely intervention and treatment are performed to control blood sugar, the k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P3/10A61P13/12
CPCA61K36/232A61K36/236A61K36/346A61K36/488A61K36/539A61K36/57A61K36/71A61K36/79A61K36/8945A61K36/8968A61K2236/333A61K2236/55A61P3/10A61P13/12A61K2300/00
Inventor 郭建鹏金成山林长青南极星朴明贯
Owner 延吉朝耀生物科技有限公司
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