Oral drop pills in use for treating diseases of bacterial infection and preparation method
A technology for bacterial infection and disease, which is applied in the direction of antibacterial drugs, respiratory diseases, and vector-borne diseases, and can solve problems that are not conducive to improving the ability of patients to seek medical treatment, bioavailability of the first-pass effect of the liver and intestines, and unfavorable overall health levels, etc. , to achieve the effect of being conducive to labor protection and environmental protection, improving bioavailability, and ensuring the quality of drugs
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[0027] Now with several groups of specific examples, the preparation method of the oral dripping pill of the present invention will be further described.
[0028] Group 1: Tests with a single matrix
[0029] 1. Preparation of the medicinal extract: Take an appropriate amount of clove leaves, add water and decoct twice, the first time is 1.5h, the second time is 1h, the decoction is combined, filtered, and the filtrate is concentrated under reduced pressure to a relative density of 1.25 (80°C) The clear paste is dried at 60°C to 80°C, crushed into fine powder, and obtained;
[0030] 2. Substrate: polyethylene glycol (2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. One or a mixture of two or more pharmaceutical carriers;
[0031] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;
[0032] 4....
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