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Oral drop pills in use for treating diseases of bacterial infection and preparation method

A technology for bacterial infection and disease, which is applied in the direction of antibacterial drugs, respiratory diseases, and vector-borne diseases, and can solve problems that are not conducive to improving the ability of patients to seek medical treatment, bioavailability of the first-pass effect of the liver and intestines, and unfavorable overall health levels, etc. , to achieve the effect of being conducive to labor protection and environmental protection, improving bioavailability, and ensuring the quality of drugs

Inactive Publication Date: 2008-02-13
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
[0007] In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] Now with several groups of specific examples, the preparation method of the oral dripping pill of the present invention will be further described.

[0028] Group 1: Tests with a single matrix

[0029] 1. Preparation of the medicinal extract: Take an appropriate amount of clove leaves, add water and decoct twice, the first time is 1.5h, the second time is 1h, the decoction is combined, filtered, and the filtrate is concentrated under reduced pressure to a relative density of 1.25 (80°C) The clear paste is dried at 60°C to 80°C, crushed into fine powder, and obtained;

[0030] 2. Substrate: polyethylene glycol (2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. One or a mixture of two or more pharmaceutical carriers;

[0031] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0032] 4....

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PUM

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Abstract

A Chinese medicine in the form of dripping pill for treating acute dysentery, enteritis, upper respiratory tract infection, sore throat, tonsillitis, etc is prepared from cloves leaf and matrix.

Description

technical field [0001] The present invention relates to a kind of medicinal composition that has heat-clearing and toxic substances removing, reducing inflammation and stopping dysentery, and is used for the treatment of bacterial infectious diseases such as acute bacillary dysentery, enteritis, upper respiratory tract infection, sore throat, acute and chronic tonsillitis, especially clove leaf A pharmaceutical composition oral drop pill preparation prepared from traditional Chinese medicine raw materials. Background technique [0002] According to the ministerial drug standard WS 3 -Yanlixiao tablet prepared by the preparation method given in B-1760-94 is a kind of heat-clearing and detoxifying, anti-inflammatory and anti-dysentery effect, which is used for the treatment of acute bacillary dysentery, enteritis, upper respiratory tract infection, and sore throat. Oral tablets for bacterial infectious diseases such as acute and chronic tonsillitis, have been clinically verif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/61A61P31/04A61P1/00A61P11/04A61K127/00
CPCY02A50/30
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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