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Application of resina ferulae in preparation of medicament for treating irritable bowel syndrome(IBS)

A technology for irritable bowel syndrome and volatile oil, which can be used in pill delivery, pharmaceutical formulations, drug combinations, etc., and can solve problems such as large toxic and side effects

Inactive Publication Date: 2008-06-25
王彦丁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are very few medicines for treating IBS in the world. According to the data, there are "Tegaserod Maleate" and "Zemaco", both of which are chemical medicines with relatively serious side effects.

Method used

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  • Application of resina ferulae in preparation of medicament for treating irritable bowel syndrome(IBS)
  • Application of resina ferulae in preparation of medicament for treating irritable bowel syndrome(IBS)
  • Application of resina ferulae in preparation of medicament for treating irritable bowel syndrome(IBS)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] The Ferulicum volatile oil of the present invention is used to prepare an IBS medicine: Ferulicum Injection, which is prepared by a conventional method.

[0089] Ferulicum volatile oil uses Xinjiang Ferulicum or Fukang Ferulicum as raw materials, and adopts the usual oil-water separation method to prepare the volatile oil. Measured in parts by weight, take 0.1-20 parts by weight of Ferulicum, add 0.1-80 parts of purified water, carry out steam distillation, control the temperature at 105-108 ° C, separate through an oil-water separator, and collect 0.012-2.4 parts of volatile oil, that is Ferulic volatile oil.

[0090] Measured according to Table 6, add ferulicum volatile oil into a solubilizer, such as 2,3-HP, β-CD, (the solubilizer is first dissolved with an appropriate amount of water for injection) and stir for 20 minutes, then add an appropriate amount of water for injection, and add an isotonic regulator to chlorinate Sodium (sodium chloride for injection), add w...

Embodiment 2

[0096] The Ferulicum volatile oil of the present invention is used to prepare the IBS medicine: Ferulic Capsules, which is prepared by a conventional method.

[0097] Take 12kg of Ferulicum volatile oil, which is equivalent to 100kg of Ferulicum. Get excipient 47.74kg, promptly weight ratio is Ferulicum volatile oil: excipient=1: 3.98, wherein, starch 25kg, compressible starch 12kg, L-HPC 8kg, microcrystalline cellulose 2.5kg, CMS-Na 0.24 kg, put the excipient in the mixer, start the machine and stir for 5 minutes, spray ferulic volatile oil evenly in the excipient, continue stirring for 5 minutes after spraying, add 5% starch slurry to make soft material, put the soft material in In the granulator, make wet granules through a stainless steel screen, dry them below 60°C to dry material, put them into the granulator, pass through the stainless steel screen for granulation, put them in a mixer, and add the lubricant stearic acid Magnesium 0.096kg, that is, excipient: lubricant ...

Embodiment 3

[0099] Ferulic volatile oil of the present invention is used to prepare IBS medicine: Ferulic dripping pills (also known as Ferulic capsules), which are prepared by conventional methods.

[0100] The volatile oil is extracted by steam distillation, separated by an oil-water separator to obtain 12kg of Ferulicum volatile oil, which is equivalent to 100kg of Ferulicum. (1) Preparation of gelatin solution: gelatin: glycerin: water = 1:0.4:1, take 7kg of gelatin, add 1.75kg of purified water to make it absorb water and swell, take another 2.8kg of glycerin and 5.25kg of purified water and heat it in a stainless steel tank for 75 Mix evenly at ℃, add expanded gelatin and stir to make it melt into a uniform solution, keep warm for 1.5h, let stand, remove the floating foam, and filter with nylon cloth. (2) Preparation of medicinal liquid (ie oil liquid): take 12 kg of the above-mentioned volatile oil, add 0.75 kg of medicinal peanut oil, and stir well. (3) Making capsules: place the...

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Abstract

The invention also relates to the use of asafetida volatile oil in preparing medicament for treating irritable bowel syndrome, which can be in the forms of injection, capsules, drop pill, tablets, granules, powder, oral liquid or other dosage forms, the asafetida volatile oil mainly contains alpha-firpene, 2-bornyl alcohol, dibutyl bisulphide, sec-butyl-trans-1-cyclobutenyl bisulphide, sec-butyl-trans-isoallyl bisulphide, dimethyl disulfide, dimethyl trisulfide, N,N-dimethyl thioformamide, and isoallyl-butyl-bisulfide.

Description

technical field [0001] The invention relates to the volatile oil of Ferulicum volatile oil produced in Iran, Afghanistan and other countries and the pharmaceutical use of Ferulic volatile oil. Background technique [0002] Asafoetida is a natural plant secretion. "Pharmacopoeia of the People's Republic of China" 2005 Edition, page 131 records: Ferulae is bitter, pungent, and warm in nature, returns to the spleen and stomach meridians, eliminates accumulation, dispels cold, and kills insects. Used for stagnation of meat, stagnation of blood in the abdomen, mass in the abdomen, and abdominal pain due to worm accumulation. "National Chinese Herbal Medicine Compilation" Volume 2, People's Health Publishing House, 1978, page 318 records: Ferulicum is pungent in nature and flavor, slightly warm, eliminates stagnation, kills insects, dispels cold, and treats mainly insect accumulation, abdominal mass, stomach and abdominal pain, malaria, dysentery, And can prevent measles. The tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P1/00
Inventor 王泽民
Owner 王彦丁
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