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Pharmaceutical composition containing ginkgo leaf extract and adrenoceptor agonist

A receptor agonist and composition technology, applied in the field of new pharmaceutical compositions, can solve the problems of no obvious advantage in therapeutic effect, complicated pathogenesis, etc., to reduce clinical dosage, sensitize bronchial expansion, and avoid myocardial infarction. Effect

Active Publication Date: 2009-06-10
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex pathogenesis of respiratory diseases such as asthma, chronic bronchitis and chronic obstructive pulmonary disease, many drugs cannot achieve satisfactory curative effect when used alone. In addition to the serious adverse reactions caused by the use of corticosteroids, there is no obvious advantage in the treatment of such diseases

Method used

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  • Pharmaceutical composition containing ginkgo leaf extract and adrenoceptor agonist
  • Pharmaceutical composition containing ginkgo leaf extract and adrenoceptor agonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 and Example 2 are animal experiments to verify the efficacy of the combined use of Ginkgo biloba extract and adrenergic receptor agonist.

[0014] Example 1

[0015] Effect of ginkgo biloba extract in combination with salmeterol or formoterol on the incubation period of histamine-induced asthma attacks in guinea pigs

[0016] 1. The purpose of the experiment:

[0017] To verify the effect of ginkgo biloba extract combined with salmeterol on the incubation period of histamine-induced asthma attacks in guinea pigs, and to find a more effective pharmaceutical composition for the treatment of respiratory diseases such as asthma, bronchitis and chronic obstructive pulmonary disease.

[0018] 2. Experimental materials

[0019] 1 Experimental animals: select juvenile guinea pigs, weighing 150-200g.

[0020] 2 Experimental instruments: air compressor, aerosol nozzle, mercury gauge, 4L glass clock set;

[0021] 3 Experimental drugs: 2% acetylcholine chloride, 0.1% histamin...

Embodiment 2

[0037] Effect of ginkgo biloba extract in combination with clenbuterol or salbutamol on the latency of histamine-induced asthma attacks in guinea pigs

[0038] 1. The purpose of the experiment:

[0039] To verify the effect of ginkgo biloba extract in combination with clenbuterol or salbutamol on the incubation period of histamine-induced asthma attacks in guinea pigs, and to find a more effective drug combination for the treatment of respiratory diseases such as asthma, bronchitis and chronic obstructive pulmonary disease Things.

[0040] 2. Experimental materials:

[0041] Ginkgo biloba extract (lactone content>80%), Clenbuterol, Salbutamol.

[0042] Same as above.

[0043] 3. Experimental method:

[0044] Select juvenile guinea pigs, both male and female, weighing 150-200 g, put them in a glass cover of about 5 liters, and spray a volume mixture of 2% acetylcholine chloride and 0.1% histamine phosphate for 15 seconds at a pressure of 400 mmHg. After the spray is stopped, observ...

Embodiment 3

[0060] Ginkgo biloba extract and salmeterol compound aerosol

[0061] Salmeterol 2.5g

[0062] Ginkgo biloba extract 200g

[0063] Ethanol 650g

[0064] Propylene glycol 250g

[0065] Dichlorodifluoromethane 1500g

[0066] Vitamin C 7.5g

[0067] Preparation Process:

[0068] Add the prescription amount of salmeterol and ginkgo biloba extract into the well-stirred vitamin C, ethanol and propylene glycol, stir and heat in a warm water bath to dissolve the raw materials, filter with sand core funnel, fill in divided doses, and seal the dose valve The system is pressurized and injected with dichlorodifluoromethane to obtain it, theoretically filling 1000 bottles, and the filling yield is above 85%. After 30 minutes of leak detection in 45-50℃ water bath, there is no leakage. 50 presses per bottle, each press contains 50μg salmeterol and 4mg ginkgo biloba extract.

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Abstract

This invention supplies a drug composition used to cure asthma, bronchitis, chronic obstructive pulmonary disease, and other respiratory diseases. The drug contains two active constituents: gingko-leaf extract and epinephrine receptor stimulator. In experiment we get a unexpected effect: the gingko-leaf extract engenders notable synergism effect with beta-epinephrine receptor stimulator, and this has crucial meaning to clinical therapy of asthma, bronchitis, chronic obstructive pulmonary disease. Compound preparation types of aerosol, spray, powder aerosol, capsule, slow release capsule, soft capsule, common tablet, slow release tablet, disperse tablet, buccal tablet, droplet, and so on are not only propitious to quickly exert drug curative effect, but also are convenient to take.

Description

Technical field [0001] The invention belongs to a new pharmaceutical composition, especially for the treatment of respiratory diseases such as asthma, chronic bronchitis and chronic obstructive pulmonary disease. Background technique [0002] The current understanding of the pathogenesis of asthma has changed from bronchial smooth muscle contraction to airway hyperresponsiveness and chronic airway inflammation. The focus of asthma treatment has also changed from bronchial expansion to anti-inflammatory therapy. Single-agent treatment of this disease should be the first choice for inhaled adrenal corticosteroids. Inhaled adrenal corticosteroids can not only effectively improve airway function, reduce symptoms, reduce the number of recurrences, but also prevent airway reconstruction that causes irreversible airway obstruction. However, asthma diseases cannot be completely cured in a short period of time. Many patients need long-term or even life-long medication. The serious adverse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61K9/12A61K9/20A61K9/48A61P11/06A61P11/00
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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