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Method for detecting medical polyethylene glycol

A technology of polyethylene glycol and glass rods, which is applied in thermal analysis of materials, instruments, measuring devices, etc., and can solve problems such as description of crystallization morphology

Active Publication Date: 2009-07-22
津药达仁堂集团股份有限公司第六中药厂
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its quality standard refers to "Chinese Pharmacopoeia" (2005 edition), but there is no description of its crystal form under the item of character identification

Method used

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  • Method for detecting medical polyethylene glycol
  • Method for detecting medical polyethylene glycol
  • Method for detecting medical polyethylene glycol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Heat medicinal polyethylene glycol 1500 to 90°C to melt, dip a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the thickness of the liquid applied on the glass slide can be controlled at 0.02 mm-0.5mm), after cooling and solidifying, place it under an optical microscope to observe the crystal form of pharmaceutical polyethylene glycol 1500. (See figure 1 )

Embodiment 2

[0020] Heat medicinal polyethylene glycol 4000 to 110°C to melt, dip a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the thickness of the liquid applied on the glass slide can be controlled at 0.02 mm-0.5mm), after cooling and solidifying, place it under an optical microscope to observe the crystal form of pharmaceutical polyethylene glycol 4000. (See figure 2 )

Embodiment 3

[0022] Heat medicinal polyethylene glycol 6000 to 110°C to melt, dip a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the thickness of the liquid applied on the glass slide can be controlled at 0.02 mm-0.5mm), after cooling and solidifying, place it under an optical microscope to observe the crystal form of pharmaceutical polyethylene glycol 6000. (See image 3 )

[0023] Figure 4 , Figure 5 and Figure 6 The photos of S-40, poloxamer and stearyl alcohol under the microscope are shown respectively (40 times magnification); through observation, there is a clear difference between pharmaceutical polyethylene glycol and their crystal forms.

[0024] Figure 7 After heating Qingyan dripping pills with polyethylene glycol as the auxiliary material to 110 ° C to melt, dip a small amount of liquid with a glass rod, and apply it thinly on the glass slide heated to the same temperature (the thickness of the liquid...

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Abstract

The invention discloses a method for identifying medicinal polyethylene glycol, which consists of the following steps: heating the medicinal polyethylene glycol to 90-110°C to melt, dipping a small amount of liquid with a glass rod, and applying it thinly Heated to the same temperature on the glass slide, after cooling and solidifying, put it under an optical microscope to observe the crystal form of the medicinal polyethylene glycol, and observe the pharmaceutical polyethylene glycol crystal with the crystal nucleus as the center through the method of the present invention. Arranged radially in strips, every intersection of three crystals is a Y-shaped angle. This crystal shape is a special morphological feature inherent in solid polyethylene glycol, which is obviously different from other auxiliary materials for dropping pills. The invention is simple and flexible. Time-saving and reliable, no complicated pre-treatment for pharmaceutical polyethylene glycol is required, and pharmaceutical polyethylene glycol can be identified objectively.

Description

technical field [0001] The invention relates to an identification method of pharmaceutical auxiliary materials, in particular to an identification method of polyethylene glycol, a commonly used auxiliary material for dropping pills. Background technique [0002] Polyethylene glycol (Macrogol) is a mixture of ethylene oxide and water polycondensation, and its molecular formula is HO(CH 2 CH 2 O) n H represents, wherein n represents the average number of oxyethylene groups. Commonly used solid polyethylene glycols have molecular weights of 1500, 4000, and 6000. Its quality standard refers to "Chinese Pharmacopoeia" (2005 edition), but its crystal form is not described in the item of character identification. Contents of the invention [0003] The purpose of the present invention is to provide a method for identifying medicinal polyethylene glycol. [0004] Technical scheme of the present invention is summarized as follows: [0005] A method for identifying medicinal po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N25/14G01N21/84
Inventor 郭景生王鑫
Owner 津药达仁堂集团股份有限公司第六中药厂
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