Medication for treating coronary heart disease and angina

Abstract

The invention provides a medicine for treating coronary heart disease and angina pectoris. The disadvantage is that it is a pharmaceutical preparation with a higher degree of naturalness, stronger safety, and lower toxic and side effects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical preparation for treating coronary heart disease and angina pectoris made from traditional Chinese medicines. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary heart disease is the abbreviation of coronary heart disease, which is a kind of coronary circulation disorder due to fixed (atherosclerosis) or dynamic (vasospasm) stenosis or obstruction of coronary arteries, which causes imbalance between myocardial oxygen supply and demand. A heart disease that causes myocardial ischemia, hypoxia or necrosis, also known as ischemic heart disease. Because of its high incidence and high mortality rate, coronary ...

AI Technical Summary

Problems solved by technology

[0005] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are the key to affect the preparation of dripping pills

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pill preparations: With the development of the economy, the market is becoming more and more internationalized, and China is trying to adapt to this trend. Currently, Chinese medicine dripping pill preparations as health food have been successfully exported to many countries. However, there are still many problems at present, because different countries have different approvals for the excipients selected for the preparation of traditional Chinese medicine dripping pills, especially Europe, which has developed industries, has stricter regulations on food excipients and pharmaceutical excipients, and those exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for the drop pill preparation are not listed in the food additive catalog of some countries, which is very unfavorable for the Chinese medicine drop pill preparation to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, It is particularly important and urgent to find one or more new matrix excipients that can be accepted by the international market

3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug

4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.

[0006] In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect through a large number of experiments and research on preparation technology. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production

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