Therapy electrode tablet clamping self-pasting medicament film and preparation method thereof
A drug-loaded film and self-adhesive technology, which is applied in the direction of electrodes, electrotherapy, and pharmaceutical formulations, can solve the problems of reducing the adhesive performance of conductive adhesives, reducing application flexibility, and increasing production costs, so as to overcome the problem of high price, The effect of reducing the competition transmission and reducing the cost of use
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Examples
Embodiment 1
[0029] 1. Preparation of buffer layer gel material
[0030] 2 grams of chitosan with a molecular weight of 300,000 and 3 grams of polyvinyl alcohol 17-99 were dissolved in 100 mL of lactic acid solution with a mass concentration of 2% and 30 mL of deionized water, and then the two solutions were mixed until uniform. While stirring, 32 grams of mass concentration are 25% gelatin (molecular weight is 150,000) solution, 40mLpH6.5 acetate buffer solution, 50 grams of mass concentration are 30% maltooligosaccharides, 50 grams of mass concentration are 40% low Polysucrose, 3 grams of glycerin, 0.1 grams of sodium benzoate and 10 grams of KCl solution with a mass concentration of 10% were added to the mixed solution, thoroughly mixed at 40-45° C. and then degassed.
[0031] 2. Preparation of drug release layer gel material
[0032] 2 grams of chitosan with a molecular weight of 300,000 and 3 grams of polyvinyl alcohol 15-99 were dissolved in 100 mL of lactic acid solution with a mas...
Embodiment 2
[0036] The preparation process of the buffer layer gel material is the same as that of Example 1, except that the pH6.5 acetate buffer solution is changed to the pH7.2 phosphate buffer solution.
[0037] The preparation process of the drug release layer gel material is the same as that of Example 1.
[0038] The preparation process of the physiotherapy electrode sheet sandwiching the self-adhesive drug-loaded film is the same as that of Example 1. In the physiotherapy electrode sheet sandwiched with the self-adhesive drug-loaded film, the thickness of the buffer layer is 0.5 mm, and the thickness of the drug-releasing layer is 0.5 mm. 0.5mm.
Embodiment 3
[0040] The preparation process of the buffer layer gel material is the same as that of Example 1, except that the pH6.5 acetate buffer solution is changed to the pH7.6 phosphate buffer solution.
[0041] The preparation process of the drug release layer gel material is the same as that of Example 1.
[0042] The preparation process of the physiotherapy electrode sheet sandwiching the self-adhesive drug-loaded film is the same as that of Example 1. In the physiotherapy electrode sheet sandwiched with the self-adhesive drug-loaded film, the thickness of the buffer layer is 0.5 mm, and the thickness of the drug-releasing layer is 0.5 mm. 0.5mm.
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Abstract
Description
Claims
Application Information
- IPC
- A61N1/04; A61N1/30; A61N1/44; A61M37/00; A61K47/36; A61K31/7048; A61K36/00; A61P17/00; A61P31/10
- Inventors
- 周雪琴; 刘东志