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Extractive of traditional Chinese medicine and capsule for treating fatty liver, and its preparing method

A technology of traditional Chinese medicine capsules and extracts, which is applied in the directions of capsule delivery, drug combination, and pharmaceutical formulations, can solve problems such as increasing liver burden, impairing liver function, promoting lipid accumulation, etc. Effective, preventive effect

Inactive Publication Date: 2007-07-25
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these drugs are aimed at a certain link or part of the pathogenesis of fatty liver, the effect is relatively single, and the effect is not ideal
Moreover, lipid-lowering drugs may tend to concentrate blood lipids in the liver for metabolism, increase the burden on the liver, instead promote the accumulation of lipids in the liver, and damage liver function. Therefore, patients with fatty liver should not blindly take lipid-lowering drugs for a long time

Method used

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  • Extractive of traditional Chinese medicine and capsule for treating fatty liver, and its preparing method
  • Extractive of traditional Chinese medicine and capsule for treating fatty liver, and its preparing method
  • Extractive of traditional Chinese medicine and capsule for treating fatty liver, and its preparing method

Examples

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Effect test

Embodiment 1

[0131] Example 1: Preparation of total coumarin and total curcumin of turmeric in the present invention:

Embodiment 1-1

[0133] Weigh 4kg of raw material medicine Yinchen, 2kg of turmeric, and 0.06kg of total saponins of ginseng stems and leaves, and spare;

[0134] Take the Yinchen raw material and extract it with supercritical CO2 for 1 hour at a pressure of 15 Pa and a temperature of 35°C. The extract is collected; the extract is added with 30% ethanol, heated to 40°C, continuously stirred, and filtered while it is hot , Discard suspended matter and insoluble matter, let the filtrate cool, separate out the precipitate, filter, wash the precipitate with 30% ethanol until it is off-white, dry, and crush to obtain the total coumarin;

[0135] Take turmeric raw material and grind it into coarse powder. Under the conditions of pressure 15MPa and temperature 35℃, use supercritical CO 2 Extract for 0.5 hour, and collect the oily material for other purposes. The extracted medicinal powder is leached with 70% ethanol twice, stirring occasionally for 10 hours each time, combining the extracts, filtering, c...

Embodiment 1-2

[0138] Weigh 5 kg of raw material medicine Yinchen, 3.75 g of turmeric, and 0.075 kg of total saponins of ginseng stems and leaves, for use;

[0139] Take Yinchen and use supercritical CO under pressure of 30MPa and temperature of 40℃ 2 Extract for 1 hour, collect the extract; add 60% ethanol to the extract, heat to 70°C, keep stirring, dissolve and filter while hot, discard the suspended matter and insoluble matter, let the filtrate cool, and precipitate the precipitate, filter, and precipitate to 60 % Ethanol wash until almost white, dried, crushed to obtain the total coumarin;

[0140] Take turmeric, grind it into coarse powder, use supercritical CO under pressure of 30MPa and temperature of 40℃ 2 After 2 hours of extraction, the oily substance obtained from the extraction was collected in another device for other use. The extracted medicinal powder was leached twice with 75% ethanol, stirred occasionally for 15 hours each time, combined the extracts, filtered, concentrated the...

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PUM

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Abstract

A Chinese medicine in the form of capsule for treating fatty liver, chronic hepatitis and hepatofibrosis is prepared from general coumarin, general curcumin, general ginsenoside and pharmacologically acceptable assistants. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the technical field of a traditional Chinese medicine extract for treating hepatitis, a traditional Chinese medicine capsule and a preparation method. Background technique: [0002] Fatty liver is a fatty liver disease caused by many reasons. When the lipid accumulation in liver cells exceeds 5%, or histologically, more than one-third of liver cells per unit area is fatty liver, it is called fatty liver. The pathogenesis of fatty liver is not yet clear. Modern medicine believes that it may be related to a variety of factors, such as abnormal lipid metabolism, changes in hormone levels, environmental and genetic factors, lipid peroxidation damage, immune response, hypoxia, and hepatic circulation disorders. Play a certain role in its pathogenesis. In recent years, due to the influence of many factors such as living habits and dietary structure, the inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K31/704A61K9/48A61P1/16A61K31/12A61K31/37
Inventor 肖小河金城周旭赵艳玲张萍
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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