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Application of pongamia pinnata extract in preparation of anti-gastric-ulcer medicament and anti-inflammation and analgesic medicament

A kind of technology of extracting and saffron, applied in the field of medicine

Inactive Publication Date: 2007-08-08
朱毅 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report about the effective parts of the root extract of P. agaricus for anti-inflammation, analgesia and anti-gastric ulcer

Method used

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  • Application of pongamia pinnata extract in preparation of anti-gastric-ulcer medicament and anti-inflammation and analgesic medicament
  • Application of pongamia pinnata extract in preparation of anti-gastric-ulcer medicament and anti-inflammation and analgesic medicament
  • Application of pongamia pinnata extract in preparation of anti-gastric-ulcer medicament and anti-inflammation and analgesic medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Preparation of the total ethanol extract of Pseudomonas japonica root: Take the dry product of Pseudomonas japonica root, pulverize it with a drug grinder, soak it in 70% ethanol, and extract it 3 times under reflux in a water bath at 60°C, and collect the reflux liquid after filtering and collecting it in a rotating Distill under reduced pressure in an evaporating flask, recover to no alcohol smell, and dry to obtain a brown dry extract.

Embodiment 2

[0014] Example 2 The preparation of the ethyl acetate extract of Pygnus japonica root: dissolve the ethanol extract with distilled water, extract with equal volume petroleum ether, ethyl acetate and n-butanol successively for 3 times, recover the solvent respectively, and vacuum dry (80° C.) Finally, petroleum ether extract, ethyl acetate extract, n-butanol extract, and the residue after extraction were obtained.

Embodiment 3

[0015] Example 3 The effect of the root extract of Pseudomonas japonica on rat ethanol-type gastric ulcer

[0016] 1. Animals: SPF grade Kunming mice, weighing 20±2g, half male and half male, certificate number: SCXK (Guangdong) 2003-0001; SPF grade SD rats, weight 180±20g, half male and half female, certificate number: SCXK (Guangdong) 2003-0002, all provided by the Experimental Animal Center of Guangdong Province. The experiment was started after male and female animals were fed with normal diet separately for 5 days. The room temperature was controlled at 22±2° C. and the humidity was 55±15%.

[0017] 2. Drugs: Cimetidine, produced by Hainan Pharmaceutical Factory Co., Ltd., batch number: 050701; Ethyl acetate extract of Pygnus japonicus root, prepared in Example 2.

[0018] 3. Experimental method: 48 clean-grade SD rats, half male and half male, were randomly divided into 7 groups: the first group took 8 above-mentioned SD rats as the model control group; the second, thir...

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Abstract

The invention relates to a method for using karanjin to prepare the drug used to treat gastric ulcer and antiphlogistic function. The invention uses the mouse alcohol gastric ulcer model and the mouse alserin gastric ulcer model, to watch the karanjin alcohol extractive on the hurt of gastric mucosa, which proves that the karanjin alcohol extractive and relative acetic acid ethyl ester extractive can significant restrain the gastric mucosa hurt. The invention uses the mouse dimethylbenzene ear expanding model and the mouse acetate ease pain test to watch the antiphlogistic function of karanjin extractive. The invention also processes the mouse acute toxicity test on the karanjin alcohol extractive, to prove the little toxicity of it.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of the extract of Pinga japonica in the preparation of anti-gastritis and gastric ulcer drugs and the application in the preparation of anti-inflammatory and analgesic drugs. Background technique [0002] Gastric ulcer is a common disease and frequently-occurring disease. At present, there are many research reports at home and abroad, but most of them are treated with chemical drugs, and there are many adverse reactions. Traditional Chinese medicine has the advantages of abundant sources, economy and low toxicity in treating diseases. And in the medicine that has been applied to clinical treatment gastric ulcer at present, there are not many Chinese medicines with definite curative effect. At present, the anti-inflammatory and analgesic drugs are mostly chemical drugs. Due to their many side effects, their use is limited. Therefore, it is of great value to deve...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K125/00A61P1/04
Inventor 朱毅刘可云
Owner 朱毅
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