Composition and great volume injection containing bromhexine salt and the injection preparing process

A technology for compositions and injections, which is applied in the field of compositions containing bromhexine salts, can solve the problems of poor stability, decreased content, easy precipitation of crystals, etc., and achieve good stability

Active Publication Date: 2007-08-22
江西亿友药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Bromhexine hydrochloride is currently commonly used bromhexine hydrochloride, because bromhexine hydrochloride is insoluble in water, affected by pH value, co-solvent and preparation method, etc., bromhexine hydrochloride is easy to precipitate
According to the current technical level, in order to obtain a stable bromhexine salt pr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Component Content (weight%)

[0024] Bromhexine Hydrochloride 0.075%

[0025] Ethanol 3.25%

[0026] Poloxamer 1.86%

[0027] Hydroxypropyl Cellulose 1.86%

[0028] Glucose 92.955%

Embodiment 2

[0030] Component Content (weight%)

[0031] Bromhexine Hydrochloride 0.32%

[0032] Ethanol 13.68%

[0033] Poloxamer 7.82%

[0034] Hydroxypropyl Cellulose 7.82%

[0035] Sodium chloride 70.36%

Embodiment 3

[0037] The hydroxypropyl cellulose in embodiment 1 is replaced by hydroxypropyl methylcellulose.

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PUM

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Abstract

The present invention discloses one kind of composition containing bromhexine salt, great volume injection and the injection preparing process. The composite includes bromhexine salt as the active component in 0.03-0.8 wt%, ethanol as co-solvent in 1.5-36 wt%, and stabilizer in 1.0-40 wt%, and has pH 3.0-7.0. The stabilizer is poloxamer, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and/or hydroxyethyl cellulose. The composition of the present invention has high stability, and may be preserved for long period without bromhexine salt crystal separated out.

Description

technical field [0001] The invention relates to a composition containing bromhexine salt, a large-capacity injection and a preparation method for the injection. Background technique [0002] Bromhexine is a synthetic analogue of orchidine, which has a strong effect of dissolving mucus, can break down the acidic mucopolysaccharide fibers in sputum, and inhibit the synthesis of acidic glycoproteins in mucous glands and goblet cells, so that The content of sialic acid, one of the acidic mucopolysaccharide components in sputum, is reduced, reducing the viscosity of sputum. In addition, bromhexine can also stimulate the gastric mucosa to reflexively increase the secretion of the respiratory glands and dilute the sputum. All of the above effects are conducive to the coughing of sputum. It is the preferred expectorant commonly used at home and abroad. [0003] Experiments have shown that bromhexine can improve the ability of antibiotics such as tetracycline, erythromycin, amoxici...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/136A61P11/10
Inventor 张嵩
Owner 江西亿友药业有限公司
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