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Chinese and Western medicine united sustained-release injection for preventing and controlling coccidiosis of rabbit and its preparation method

A slow-release injection and rabbit coccidiosis technology, which is applied in the direction of medical formula, drug combination, anti-infective drugs, etc., can solve the problems of reducing the cost of medication, reducing the amount of prevention and treatment drugs, and prolonging the effective control time, so as to reduce the amount of western medicine, Delaying the emergence of drug resistance and facilitating the promotion and application of drugs

Inactive Publication Date: 2007-12-12
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the shortcomings of Western medicines that easily cause coccidia to develop drug resistance and the difficulty of taking prescribed doses of Chinese herbal medicines through oral administration, which affect the curative effect and slow drug effect, and provide a medicine that can appropriately reduce the dosage of Western medicines and is not affected by appetite. , the dosage is accurate, and greatly reduces the amount of prevention and treatment drugs, prolongs the effective control time, reduces the cost of medication, delays the development of drug resistance of coccidia, and achieves the safe and effective injection of Chinese and Western medicine combined slow-release preparations for the prevention and treatment of rabbit coccidiosis; Another object of the present invention is to provide the preparation method of this combined Chinese and Western medicine sustained release agent

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1: (Prevention and treatment of rabbit coccidiosis Chinese and Western medicine combined slow-release injection preparation 1)

[0036] (1) Dry Artemisia annua, Sophora flavescens, Pulsatilla pulsatillae, Agrimony, Bupleurum, Burnet, and Astragalus in a blast oven at 45-50°C for more than 4 hours, and grind them into fine powders with a traditional Chinese medicine grinder; weigh Take crushed Artemisia annua 30, Sophora flavescens 58g, Pulsatilla pulsatilla 20g each, Agrimony 47g, Bupleurum 10g, Burnet 30g, Astragalus 12g each, mix well, and set aside;

[0037] (2) Mix the medicinal powder in step (1), add 95% ethanol to soak and extract twice, the amount of ethanol added each time is 1cm above the medicinal surface, the container is sealed to prevent ethanol volatilization, stir 1-2 times a day during the soaking process, 3 Two days later, the extract was separated by centrifugation, the two extracts were combined, heated to boiling in a water bath, cooled a...

Embodiment 2

[0044] Embodiment 2: (Prevention and treatment of rabbit coccidiosis Chinese and Western medicine combined slow-release injection preparation 2)

[0045] In this example, weigh 40g of crushed Artemisia annua, 38g of Sophora flavescens, 35g of Pulsatilla chinensis, 36g of Agrimony, 19g of Bupleurum, 20g of Burnet ulca, and 30g of Astragalus; The soaking time is 2 days; the soaking time in water is 2 days each time; 1.74g of primaquine is weighed and dissolved in 7ml of distilled water; 30g of β-cyclodextrin is weighed; Finally, each milliliter of the medicinal liquid contains 1.0 g of Chinese herbal crude drug and 0.008 g of primaquine.

Embodiment 3

[0046] Embodiment 3: (preparation 3 of Chinese and Western medicine combined sustained-release injection for preventing and treating coccidiosis in rabbits)

[0047] In this example, weigh 40g of crushed Artemisia annua, 40g of Sophora flavescens, 35g of Pulsatilla chinensis, 35g of Agrimony, 10g of Bupleurum, 20g of Burnet ulca, and 30g of Astragalus; The time is 3 days; the soaking time in water is 3 days each time; 1.47g of primaquine is weighed and dissolved in 7ml of distilled water; 30g of β-cyclodextrin is weighed; Finally, each milliliter of medicinal liquid contains the equivalent of 1.0 g of Chinese herbal crude drug and 0.007 g of primaquine.

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Abstract

The invention relates to a combination Western-Chinese pharmaceutical slow release injection for treating rabbit coccidiosis and process for preparation, wherein the constituents of the injection include (by weight percent): sweet wormwood 3-6 parts, flavescent sophora root 3-6 parts, Chinese pulsatilla root 2-5 parts, hairy vein agrimony 2-5 parts, bupleurum root 1-3 weight parts, garden burnet root 1-3 parts, astragalus root 1-3 parts, primaquine 0.06-0.35 part, beta-cyclodextrin 2-4 parts. The preparing process consists of drying the raw material herbs, disintegrating, mixing, ethanol extracting, water extracting, removing foreign substance, mixing the extract with primaquine and beta-cyclodextrin, grinding, dressing and adjusting soup volume.

Description

technical field [0001] The invention belongs to the technical field of drug prevention and control of livestock and poultry parasites, and relates to an injection-type Chinese and Western medicine combined slow-release agent for preventing and treating coccidiosis in rabbits and a preparation method thereof. Background technique [0002] Coccidiosis is the most serious parasitic disease to rabbit industry and chicken industry. The fatality rate of coccidiosis to rabbits can reach 40-80%, and the cost of anticoccidial drugs in my country is as high as billions of yuan every year. Up to now, the main means of controlling coccidiosis still relies on the chemical control of coccidiostats, such as diclozil and prohexidine. Due to the long-term use of anticoccidiostats, coccidial drug resistance has become an unavoidable serious problem. As Schnitzer and Grunberg (1975) said, "Drug resistance always develops inseparably with the development of chemotherapy, and the history of a ...

Claims

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Application Information

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IPC IPC(8): A61K36/739A61K31/47A61P33/02
Inventor 卢福庄张雪娟季敬余付媛冯尚连汪承相程菊芬周永学陈学智徐海风
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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