Phenols glycosides compounds with liveness against osteosporosis

An anti-osteoporosis, compound technology, applied in the field of medicine, can solve problems such as no anti-osteoporosis activity

Inactive Publication Date: 2008-01-23
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported that phenolic glycosides such as curculigoside, curculigoside B and curculigoside C were extracted and separated from Curculigo curculifolia (Kubo M.et.al.Journal of Medicinal Plant Research.1983, 47:52-55; Xu Jun Ping, Acta Pharmaceutica Sinica, 1992, 27(5): 353-357; Fu Da-Xu.et al.Acta Botanica Sinica, 2004, 46(5): 621-624), but no anti-osteoporosis active report

Method used

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  • Phenols glycosides compounds with liveness against osteosporosis
  • Phenols glycosides compounds with liveness against osteosporosis

Examples

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Embodiment 1

[0022] Example 1. Preparation of Curculigoside, Curculigoside B and Curculigoside C

[0023] Curculigo curculigo medicinal material 10kg, pulverized, reflux extraction with 70% ethanol as usual, the extract was recovered solvent and condensed into a paste, that is Curculigo curculigo extract. After diluting the extract with water, extract it with petroleum ether, dichloromethane, and ethyl acetate successively, concentrate the ethyl acetate extract into an extract, perform silica gel column chromatography, and use dichloromethane:methanol 60:1~1 :1 system for gradient elution, collect 20:1, 15:1 and 10:1 fractions respectively, carry out Sephadex column chromatography, and then recrystallize with methanol for 3 times to obtain 18.6 g of Curculigoside and Curculigoside Glycoside B 22.5g and Curculigoside C 3.2g.

[0024] In vitro test: Osteoporosis is a common and frequently-occurring disease in the elderly. Low bone mass caused by rapid loss of bone mass is the most importan...

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Abstract

The invention relates to the technical field of medical technology, in particular to the application of phenolic glycoside compounds, such as rhizoma curculiginis glucoside, rhizoma curculiginis glucoside B and rhizoma curculiginis glucoside C separated from rhizoma curculiginis in preparing anti-osteoporotic drug. The chemical constitution of the invention is shown in the chart: wherein, R1 indicates-OCH3 or-OH; R2 indicates-H or OH. When R1 is set as-OCH3 and R2 is set as-H, the compound will be rhizoma curculiginis glucoside; when R1 is set as-OH and the R2 is set as-H, the compound will be rhizoma curculiginis glucoside B; when R1 is set as-OCH3 and R2 is set as-OH, the compound will be rhizoma curculiginis glucoside C. After testing, it is proved that the three compounds will outstandingly promote the multiplication of osseus cell, improve activity of alkaline phosphatase, enhance the synthetization of collagen, inhibit the activity of tartrate-resistent acid phosphotase and bone resorption as well as reduce the osseous loss by enhancing the osseous formation and inhibiting the destructive bone resorption. Therefore, the invention, with the activity of resisting osteoporosis, can be applied to prepare the anti-osteoporotic drug.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the use of phenolic glycoside compounds curculigoside, curculigoside B and curculigoside C extracted and separated from Curculigo curculifolia for preparing anti-osteoporosis drugs. Background technique [0002] Curculigo orchioides Gaertn. is the dry rhizome of Curculigo orchioides Gaertn., a plant of Amaryllidaceae. It has acrid taste and hot nature. It has the functions of nourishing kidney yang, strengthening muscles and bones, and dispelling cold and dampness. And yang deficiency cold diarrhea embolism. It has been reported that phenolic glycosides such as curculigoside, curculigoside B and curculigoside C were extracted and separated from Curculigo curculifolia (Kubo M.et.al.Journal of Medicinal Plant Research.1983, 47:52-55; Xu Jun Ping, Acta Pharmaceutica Sinica, 1992, 27(5): 353-357; Fu Da-Xu.et al.Acta Botanica Sinica, 2004, 46(5): 621-624), but no anti-osteoporosis ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P19/10
Inventor 张巧艳曹大鹏秦路平韩婷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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