Smectite turbid liquor for treating non-infectious diarrhea and method for preparing the same

A non-infectious diarrhea and suspension technology, applied in the direction of liquid delivery, emulsion delivery, aluminum/calcium/magnesium active ingredients, etc., can solve the problem of easy aggregation and agglomeration of particles

Active Publication Date: 2008-01-30
NANJING BAIJINGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface area per gram of montmorillonite can reach 100m 2 Above, although the natural montmorillonite particles are fine, the particles are easy to aggregate and agglomerate during the drying process, causing the flaky particles to overlap.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 montmorillonite suspension and preparation method thereof

[0023] A kind of montmorillonite suspension for the treatment of non-infectious diarrhea, it is made of the raw materials of following weight ratio, calculated according to the content in every 100 bottles of 9000ml:

[0024] 900g of montmorillonite, 224.7g of glucose, 2.1g of sodium saccharin, 1.2g of vanillin, 27g of sodium benzoate, and the balance is purified water.

[0025] The preparation steps of this montmorillonite suspension are as follows:

[0026] (1), add the purified water of prescription quantity 2 / 3 in the preparation tank, slowly add the montmorillonite raw material of prescription quantity in the preparation tank, soak for 30 minutes;

[0027] (2), add the adjuvant of recipe quantity respectively, i.e. glucose, vanillin, sodium saccharin, sodium benzoate are stirred in the preparation tank, and make up to the recipe quantity water,

[0028] (3), above-mentioned liquid is sucked ...

Embodiment 2

[0031] The clinical trial of embodiment 2 montmorillonite suspensions

[0032] In order to evaluate the clinical efficacy and safety of montmorillonite suspension in the treatment of non-infectious diarrhea, Qilu Hospital of Shandong University was responsible for the clinical research, and Shandong Provincial Hospital and Affiliated Hospital of Qingdao University were participating units. (SDA) issued the "New Drug Approval Measures" and my country's "New Drug (Western Medicine) Clinical Research Guidelines", formulate this clinical research plan,

[0033] This clinical trial adopts a multi-center, randomized, double-blind, double-dummy, positive drug parallel controlled trial design. A total of 63 cases of non-infectious acute diarrhea were observed, including 32 cases in the test group and 31 cases in the control group. The course of treatment was 3 days. 66 cases of chronic diarrhea, including 33 cases in the test group and 33 cases in the control group, the course of trea...

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PUM

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Abstract

The present invention discloses a montmorillonite suspension to treat non-infectious diarrhea, which is made by montmorillonite, glucose, sodium saccharin, vanillin, sodium benzoate and purified water with certain mix ratio by weight. The preparation method is that the montmorillonite is placed in a preparation tank, the water is added for soaking; then the excipients which are glucose, sodium saccharin, vanillin, sodium benzoate are added and the purified water is supplemented to the prescription dose, fully agitated, the liquid is placed in a colloid mill for milling and refining, after that the liquid can pass through a 325 mesh screen, the screened liquid is cooled down to room temperature after the agitating under the heating condition, the purified water is supplemented to the prescription dose, then the invention is made by fully agitating. Montmorillonite is made into the suspension, thus having finer particles, greater absorption force, stronger effects of gastrointestinal mucosal protection and elimination of pathogens, and faster application of the pharmacological role.

Description

technical field [0001] The invention relates to a montmorillonite suspension for treating non-infectious diarrhea and a preparation method thereof. Background technique [0002] According to the course of the disease, diarrhea can be divided into acute diarrhea (with a course of less than 2 weeks), persistent diarrhea (with a course of 2 weeks to 2 months) and chronic diarrhea (with a course of more than 2 months). According to the etiology, it can be divided into infectious diarrhea (such as rotavirus, bacteria, etc.) and non-infectious diarrhea (such as dietary diarrhea, allergic diarrhea, etc.). Smecta (montmorillonite powder) was registered and marketed in France in 1975, and has been successfully used in the treatment of diarrheal diseases in more than 60 countries around the world in 2002. my country approved the import of Smecta in 1990, the license number is X900065. Before the domestic montmorillonite powder came into the market, the annual sales of Smecta in Chin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K9/10A61P1/12
Inventor 杨倬英
Owner NANJING BAIJINGYU PHARMA
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