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Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders

A technology of immune regulation and compounds, applied in the direction of drug combination, allergic diseases, respiratory diseases, etc., can solve the problems of few patients

Inactive Publication Date: 2008-02-13
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few patients achieve complete remission

Method used

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  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders

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Embodiment Construction

[0023] A first embodiment of the present invention includes a method of treating, preventing or managing an asbestos-related disease or condition comprising administering to a patient in need thereof a therapeutically or prophylactically effective amount of an immunomodulatory compound or a pharmaceutically acceptable salt thereof , solvate, hydrate, stereoisomer, clathrate or prodrug.

[0024] In the present invention, the terms "asbestos-related disease, condition or syndrome", "disease or condition associated with asbestos exposure" and "disease or condition associated with asbestos poisoning" refer to those related to or involving asbestos exposure or asbestos poisoning to their diseases, conditions, syndromes or abnormalities. These terms include benign and malignant diseases or conditions including, but not limited to, mesothelioma, asbestosis, malignant pleural effusion, benign exudative effusion, pleural plaque, pleural calcification, diffuse pleural thickening, round ...

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Abstract

Methods of treating, preventing and managing an asbestos-related disease or disorder are disclosed. Specific embodiments encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and / or chemotherapy, surgery, or radiation therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in the methods of the invention are also disclosed.

Description

1. Field of invention [0001] The present invention relates to methods of treatment, prevention and management of asbestos-related diseases or conditions comprising the administration of immunomodulatory compounds alone or in combination with known treatments. The invention also relates to pharmaceutical compositions and dosage regimens. In particular, the invention encompasses the use of immunomodulatory compounds in combination with surgery or radiation therapy and / or other standard therapies for the treatment of diseases associated with asbestos poisoning. 2. Background of the invention [0002] 2.1 Asbestos-related diseases or conditions [0003] Worldwide, millions of people are exposed to asbestos in the mining of minerals or in the manufacture and use of asbestos products. D. R. Aberle, Seminars in Roentgenology, 24(2):118, 1991. If the multiple pathological consequences of asbestos develop latently for a long time, asbestos-related diseases will become the main occ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04C07D401/00A61K31/00A61K31/4525A61K31/454A61K38/19A61K38/20A61K38/21A61K45/06
CPCA61K31/4525A61K31/00A61K38/21A61K38/193A61K31/454A61K38/2013A61K45/06A61K38/19A61P11/00A61P35/00A61P37/02A61K2300/00A61K31/4422
Inventor 杰罗米·B·杰奥迪斯
Owner CELGENE CORP