Process of purifying tadalafil

A tadalafil and solution technology, applied in organic chemistry, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as increasing production costs of tadalafil
CN101128463AInactive Publication Date: 2008-02-20TEVA PHARMA IND LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TEVA PHARMA IND LTD
Publication Date
2008-02-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides tadalafil of high purity and processes of making such tadalafil by cyclization of TDCl in a solution.
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Description

[0001] related application

[0002] This application claims the benefit of U.S. Provisional Application 60 / 656,664, filed February 25, 2005; U.S. Provisional Application 60 / 683,058, filed May 19, 2005; U.S. Provisional Application 60 / 736,807, filed November 14, 2005; and Priority to US Provisional Application 60 / 737,080, filed November 15, 2005, and US Provisional Application 60 / 677,514, filed May 3, 2005. The contents of these applications are hereby incorporated by reference. technical field

[0003] The present invention relates to a method of purifying tadalafil by crystallization. Background technique

[0004] Tadalafil, (6R-trans)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2- Methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, which has the structural formula shown below, is a white crystalline powder . (CAS#171596-29-5). Tadalafil is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase PDE5. Inhibiting...

Claims

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