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Compound medicament for treating rigidity rachitis

Ankylosing spondylitis and drug technology, applied in the direction of drug combination, antipyretics, anti-inflammatory agents, etc., can solve the problems of limited clinical application of side effects, multiple side effects, and inability to control the development of the disease well

Active Publication Date: 2008-02-27
BEIJING TONGRENTANG HEALTH PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-steroidal anti-inflammatory drugs, as traditional drugs for the treatment of AS, have played an active role in the treatment and improvement of the quality of life of patients, but the side effects of these drugs on the gastrointestinal tract and nephrotoxicity make their clinical application largely restricted. limit
Chronically acting drugs have played a certain role in slowing or preventing the development of the disease, but these drugs have many side effects, in addition to gastrointestinal reactions, there are nervous system, leukopenia, rash, bone marrow suppression, liver damage, lung lesions and other adverse reactions
Although glucocorticoids have strong anti-inflammatory and analgesic effects, they cannot well control the development of AS, cannot slow down the course of ankylosing spondylitis, and have many side effects. Long-term use does more harm than good. not for routine use
In recent years, new biological agents for the treatment of AS have been developed at home and abroad to alleviate and improve the condition, but due to infusion reactions, delayed allergic reactions, chances of infection, and high prices, clinical use is greatly limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Honeysuckle 350g Epimedium 210g Smilax 140g Phellodendron 140g

[0037] Psoralen 140g Radix Paeoniae Rubra 210g Atractylodes 140g Dipsacus 140g

[0038] Cistanche 140g, Sichuan Achyranthes bidentata 140g, Gentiana 140g, Iron wire Clematis 140g

[0039] For the above 12 herbs, volatile oil is extracted from Atractylodes atractylodis, and the volatile oil is clathrated with beta-cyclodextrin at a temperature of 40°C; the amount of beta-cyclodextrin is 1ml of essential oil plus 4g; stirring time is 3 hours, dried at 40°C, and distilled The aqueous solution is collected in another device; the dregs and Cortex Phellodendri, Psoraleae, Dipsacus, Cistanche, Achyranthes bidentata, Gentiana chinensis, and Clematis clematis add 7 times the amount of 75% ethanol, reflux extraction twice, each time for 2 hours, and filter , combined the filtrates, reclaimed ethanol and concentrated to a clear paste with a relative density of 1.10-1.15 (60°C); the four herbs of honeysuckle, epimedi...

Embodiment 2

[0041] Honeysuckle 140g Epimedium 70g Smilax 35g Phellodendron 35g

[0042] Psoralen 35g Radix Paeoniae Rubra 70g Atractylodes 35g Dipsacus 35g

[0043] Cistanche 35g, Sichuan Achyranthes bidentata 35g, Gentiana chinensis 35g, Iron wire clematis 35g

[0044] Add 10 times the amount of water to Atractylodes atractylodes above, steam distill for 8 hours, extract volatile oil, and collect the distilled aqueous solution in a separate container. Medicinal residues are mixed with Phellodendron Phellodendri, Psoralen, Dipsacus, Cistanche, Achyranthes bidentata, Gentiana chinensis, and Tiesiweiling Xianjia 80% ethanol reflux extraction 3 times, 2 hours each time, filter, combine the filtrate, recover ethanol and concentrate to a clear paste; add 10 times the amount of honeysuckle, epimedium, red peony, and Smilax to decoct in water Boil 3 times, 2 hours each time, filter, combine the filtrate, combine the filtrate with the above aqueous solution, concentrate to a clear paste, add the...

Embodiment 3

[0046] Honeysuckle 490g Epimedium 350g Smilax 245g Phellodendron 245g

[0047] Psoralen 245g Radix Paeoniae Rubra 350g Atractylodes 245g Dipsacus 245g

[0048] Cistanche 245g, Sichuan Achyranthes bidentata 245g, Gentiana 245g, Iron wire Clematis 245g

[0049]Add 15 times the amount of water to Atractylodes atractylodes above, steam distill for 4 hours, extract the volatile oil, and wrap the volatile oil with beta-cyclodextrin (volatile oil-beta-cyclodextrin-water=1:6:60, stir at 50°C for 1 hour ), refrigerate overnight, filter, dry the inclusions at low temperature (50°C), and crush them into fine powder; the distilled aqueous solution is collected in another device, and the dregs are mixed with Phellodendron Phellodendri, Psoralen, Dipsacus, Cistanche, Achyranthes bidentata, and Gentiana , Iron wire Clematis plus 60% ethanol reflux extraction 3 times, 2 hours each time, combine the extracts, recover ethanol and concentrate properly; add 12 times the amount of water to decoct...

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PUM

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Abstract

The invention relates to a Chinese compound medicament for treating ankylosing spondylitis, wherein the raw materials of the effective composition include honeysuckle flower, epimeddium, poria cocos, corktree bark, psoralea fruit, radix paeoniae rubrathe, atractylodes rhizome, dipsacus root, broomrape, achyranthes and cyathula root, large-leaf gentian root and Clematis chinensis. Various oral preparations and externally-used preparations can be obtained through processing the medicinal herbs with specific processes and / or charging pharmaceutically acceptable auxiliary materials.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for ankylosing spondylitis, in particular to a medicine for treating ankylosing spondylitis containing honeysuckle, epimedium, smilax, Phellodendron cortex and the like. Background technique [0002] Ankylosing spondylitis (Ankylosiny Spondlitis.AS) is a systemic, chronic, autoimmune disease of unknown cause. Lesions primarily involve the sacrohip joints and spine, causing ankylosis and fibrosis. In most patients, the sacrohip joint is first affected, and then develops upward to the cervical spine, manifested as recurrent lumbosacral pain, low back pain, and a sense of stiffness, especially in the morning, limited lumbar mobility, late spinal stiffness, and spinal kyphosis Deformity, some patients can affect the peripheral joints, affecting the hip joint can cause femoral head necrosis. The onset of this disease is hidden, the first symptoms are changeable,...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P19/08A61P19/02A61P29/00
Inventor 冯兴华
Owner BEIJING TONGRENTANG HEALTH PHARMA
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