Pharmaceutical composition for improving curative effect of indole-3-methanol and derivant thereof

A technology of derivatives and compositions, applied in the field of substances and pharmaceutical compositions, can solve problems such as adverse reactions and achieve the effect of enhancing effects

Inactive Publication Date: 2008-03-12
BEIJING HEBABIZ BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is because metabolites of I3C may accumulate in the liver, causing adverse effects as described above

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method 1 of embodiment 1 reduced selenium

[0038] After dissolving 3000 mg of selenium in 1000 ml of water, add 9000 mg of vitamin C (ascorbic acid), stir and react at room temperature for 3 hours to form a red transparent solution, dry directly or add some auxiliary materials such as starch, chitosan, microcrystalline cellulose, Trehalose, maltose, and maltose ketose are dried into powder or granules.

Embodiment 2

[0039] The preparation method 2 of embodiment 2 reduced selenium

[0040]Similar to Example 1, the difference is that 9000 mg of tea polyphenol (polyphenol) is added to the selenium solution to form reduced selenium.

Embodiment 3

[0041] Embodiment 3 antineoplastic drug formula 1 (control formula)

[0042] Dosage form: capsules.

[0043] Each capsule contains the following ingredients:

[0044] Indole-3-carbinol 100mg

[0045] Reduced selenium 0 micrograms

[0046] Microcrystalline Cellulose 10 mg

[0047] Cornstarch 240 mg

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PUM

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Abstract

The invention provides a number of substances, which increases the curative effect of anti-cancer Indole-3-methanol (I3C) and derivatives, including reduction selenium, vitamin B6, Beta-sitosterol, vitamin D, vitamin E, resveratrol and other substances. The reduction selenium or the medicine combination of reduction selenium and one or a plurality of other substances, or the medicine compound of the substances and Indole-3-methanol and derivatives can obviously increase the anti-cancer effect of the Indole-3-methanol and derivatives. With curative or auxiliary curative effect, the invention in particular can effectively cure prostatic hyperplasia and prostate cancer, thus reducing the dosage of Indole-3-methanol and derivatives.

Description

Technical field: [0001] The invention relates to a substance and a pharmaceutical composition for improving the therapeutic effect of indole-3-carbinol. Background technique: [0002] There are about 500,000 prostate cancer patients and 30 million benign prostatic hyperplasia or prostate tumors worldwide each year. And increase at an annual rate of 2.3%. Prostate cancer is the second leading cause of death in the United States. Currently there is no effective treatment drug. [0003] Indole-3-carbinol (indole-3-carbinol, hereinafter referred to as I3C), also known as aldol-indole-3-carbinol, is a natural compound commonly found in cruciferous vegetables such as kale. The chemical structure is now very clear. After indole-3-carbinol is metabolized in the human body, some derivatives such as 3'3-diindolylmethane (DIM) and indole (3,2b) carbazole (ICZ) will be formed. [0004] I3C and its derivatives are beneficial to the prevention and treatment of various human cancers, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K31/404A61K31/407A61P35/00
Inventor 詹姆斯·周
Owner BEIJING HEBABIZ BIOTECHNOLOGY CO LTD
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