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Application of notoginsen triterpenes and its monomer in preparing medicament for treating melancholia

A technology of Panax notoginseng saponins and monomers, applied in the application field of Panax notoginseng saponins and its monomers in the preparation of drugs for the treatment of depression, which can solve the problems of difficult to obtain satisfactory curative effect of drugs, large toxic and side effects, narrow antidepressant spectrum, etc. question

Inactive Publication Date: 2008-04-02
INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Modern medical research shows that the pathogenesis of depression is complex, with many causes and various clinical symptoms, and it is often difficult to achieve satisfactory curative effect with drugs targeting a single link
Most synthetic depressants have shortcomings such as narrow antidepressant spectrum and large toxic side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, mouse forced swimming test

[0013] Using the mouse depression model-forced swimming test (FST), specifically:

[0014] ICR male mice, weighing 18-20g, fed for three days, free to eat, 90 mice were randomly divided into 9 groups: blank (water 10ml / kg) positive (fluoxetine) and seven different doses of notoginseng Total saponins were intragastrically administered in each group. Administration was administered 30 minutes before the start of the experiment, and then the mice were put into a 10cm-diameter, 25°C, 10cm-high water glass tank to swim for 6 minutes, and the immobility time of the last 4 minutes was recorded. Compare whether there is a significant difference between the immobility time of the administration group and the blank group. The results are shown in Table 1, indicating that each group has a significant difference compared with the blank group, and can significantly improve the immobility time of the mouse forced swimming test.

[0015] T...

Embodiment 2

[0017] Embodiment 2, mouse tail suspension experiment

[0018] The results of Example 1 were verified by mouse tail suspension experiment, and the experimental method was as follows:

[0019] ICR male mice, ICR male mice, body weight 18-20g, feeding stable for three days, free to eat, 90 mice were randomly divided into 9 groups: blank (water 10ml / kg) positive (fluoxetine) and seven different doses of Panax notoginseng total saponins. All groups were intragastrically administered. After 30 minutes of administration, tie the mouse tail 1cm with a nylon rope, hang it upside down at 15cm from the bottom, observe the absolute immobility time of the mice within 6 minutes, and compare the administration group with the blank group (10ml water / kg) Is there any significant difference in immobility time. The results are shown in Table 2,

[0020] Table 2. Comparison of the effects of Panax notoginseng saponins on the immobility time of tail-suspension mice

[0021] group

Embodiment 3

[0022] Embodiment 3, mouse forced swimming experiment

[0023] Using the mouse depression model-forced swimming test (FST), specifically:

[0024] ICR male mice, weighing 18-20g, fed for three days, free to eat, 70 mice were randomly divided into 7 groups: blank (water 10ml / kg) positive (fluoxetine) and five same dose of Panax notoginseng Monomer, all groups were administered intragastrically. Administration was administered 30 minutes before the start of the experiment, and then the mice were put into a 10cm-diameter, 25°C, 10cm-high water glass tank to swim for 6 minutes, and the immobility time of the last 4 minutes was recorded. Compare whether there is a significant difference between the immobility time of the administration group and the blank group. The results are shown in Table 3, which shows that there are significant differences between the notoginseng monomer Rb1, Rd, and Re group compared with the blank group. Oral administration of notoginseng monomer Rb1, Rd,...

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PUM

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Abstract

The invention discloses a new purpose of panax notoginseng saponins and the monomer saponin, that is, the application of the panax notoginseng saponins and the panax notoginseng saponins in preparation of drugs to prevent and / or treat depression.

Description

technical field [0001] The present invention relates to a new application of Panax notoginseng saponins and Panax notoginseng monomers, in particular to the application of Panax notoginseng saponins and its monomers in the preparation of medicines for treating depression. Background technique [0002] Depression is a common and frequently-occurring disease that endangers the physical and mental health of all human beings. With the quickening pace of modern life, its incidence rate is rising rapidly. One-third of the global population will suffer from depression in their lifetime, and WHO estimates that there are more than 300 million people with depression worldwide. Epidemiological survey results show that the lifetime risk of depression is 10-25% for foreign females and 5-12% for males. Currently, depression ranks fourth among diseases threatening human health, and it is predicted that by 2020, depression will become the second largest disease, second only to heart disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P25/24
Inventor 任贵兴么杨马挺军陕方
Owner INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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