Method for treating advanced ovarian cancer with doxorubicin entrapped in liposomes

A technology of doxorubicin and liposomes, which can be used in liposome delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as toxicity and no overall survival rate.

Inactive Publication Date: 2008-04-16
ALZA CORP
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Problems solved by technology

However, randomized trials have not shown good results in overall survival of patients treated with prolonged chemotherapy, and additional cycles of chemotherapy can lead to severe toxicity (Hakes, T.B., et al., Gynecol. Oncol., 45 (3): 284-9 (1992); Bertelsen, K. et al., Gynecol. Oncol. 49 (1): 30-3691993); Lambert et al., Int. J. Gynecol. Cancer, 5(1): 41 (1995))

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  • Method for treating advanced ovarian cancer with doxorubicin entrapped in liposomes

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Embodiment 1

[0024] Treatment of patients with advanced ovarian cancer

[0025] Twenty-nine patients with suboptimally resected epithelial ovarian cancer who had been histologically determined to be FIGO stage IIIc or IV and who had achieved clinically definite completeness after six courses of platinum / paclitaxel-based chemotherapy were selected. answer. A clinically defined complete response was defined as no evidence of disease on physical examination and computed tomography testing, and CA-125 ≤ 35 units / mL. All patients had a physical status of 0-2 according to Zubrod's standard. The mean age of the patients was 57 (age range 46-79). At the time of initial cytoreductive surgery, 26 patients had FIGO stage IIIC tumors and 3 patients had stage IV tumors. All patients belonged to the case of suboptimal tumor resection. Eighteen patients had papillary serous histology, 6 patients had endometrioid histology, and 5 patients had mixed histology. The patient demographics are shown in Tab...

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Abstract

A method for treating advanced epithelial ovarian cancer patients who attain a clinically-defined complete response after initial platinum / paclitaxel-based chemotherapy is described. The method involves administering a chemotherapeutic agent, such as doxorubicin, entrapped in liposomes.

Description

technical field [0001] The subject matter described herein relates to methods of treating advanced ovarian cancer in patients who have previously received platinum / paclitaxel-based chemotherapy. More specifically, the subject matter relates to methods of treating treatment-experienced patients with advanced ovarian cancer with doxorubicin encapsulated in liposomes. Background technique [0002] Ovarian cancer is the leading cause of death in patients with gynecological malignancies. The estimated number of cases and deaths in 2005 were 22,220 and 16,210, respectively (Jemal A., et al., CA Cancer J. Clin., 55(1):10-30(2005)). Most women diagnosed with advanced epithelial ovarian cancer show a clinically sound response to platinum / paclitaxel chemotherapy (Cannistra, S.A., N. Engl. J. Med., 351 (24): 2519-29 (2004)). Overall response rates can exceed 70%, with complete clinical response rates of approximately 30-50% for patients with suboptimally resected disease (McGuire, W...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/127A61P35/00
CPCA61K9/0019A61K31/704A61K9/1271A61P35/00A61K9/127
Inventor R·D·阿尔瓦雷斯M·J·小斯特劳恩
Owner ALZA CORP
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