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Method for preparing total flavone of bidens bipinnata

A technology of Radix vulgaris and total flavonoids is applied in the field of preparation of active ingredients of natural medicines, which can solve the problems of large resin loading, low content of total flavonoids in products, low product yield and the like, and achieves the effect of reducing the load.

Inactive Publication Date: 2008-05-28
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as the literature (1, Wei Yingqin, Ma Yi, etc. Study on the separation and purification of total flavonoids of Acanthopanax sp. by macroporous adsorption resin. Shizhen Guoyi Guoyao [J]. 2006, 17(11): 2257-2258; 2. Zhong Mingmei, Chen Feihu etc. Orthogonal design method to optimize the extraction process of total flavonoids in Acanthopanax. Shizhen Guoyi Guoyao [J]. 2006, 17 (12): 2520-2521), these methods are too simple to deal with raw materials, and the obtained The total flavonoid content of the product is relatively low, and the impurity content is relatively high, and the load on the resin is too large, and the amount of resin is too much
Chinese patent CN1899340A discloses a method for obtaining the total flavonoids of P. sp. The yield is low, the final product is 40g in 10kg of dried ghost needle grass medicinal materials, and the loss of raw materials is large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Dry 10kg of ghost needle grass leaves, reflux extraction with 10 times the amount of 70% ethanol for 3 times, each time for 1.5h, filter, combine the filtrate, and concentrate the filtrate under reduced pressure until the ethanol content in the medicinal solution is about 10%, and the concentration of the medicinal solution is About 0.8g per milliliter of the leaves of P. japonica, put it in a cold place for 24 hours, precipitate the insoluble matter, centrifuge, discard the precipitate, extract and degrease the supernatant with n-hexane (1 / 2 the volume of the medicine solution x 3 times), decompress the medicine solution Concentrate and remove the residual organic solvent, then extract with a 4:1 water-saturated n-butanol-ethyl acetate mixed solvent until the color of the extract becomes lighter, combine the mixed solvent extracts, concentrate under reduced pressure to remove the solvent, and concentrate Disperse the solution with a small amount of distilled water, put ...

Embodiment 2

[0032] 10kg of the whole herb of P. japonica, reflux extraction with 8 times the amount of 60% ethanol for 3 times, each time for 1h, filter, combine the filtrate, and concentrate the filtrate under reduced pressure until the ethanol content in the liquid is about 15%, and the concentration of the liquid is about Each milliliter contains 0.85g of the whole herb of ghost needle grass, put it in a cold place for 24 hours, precipitate the insoluble matter, centrifuge, discard the precipitate, extract the supernatant with n-hexane (1 / 2 the volume of the medicine solution x 3 times) to degrease, and decompress the medicine solution Concentrate, remove the residual organic solvent, then extract with n-butanol saturated with water, until the color of the extract becomes light, combine the n-butanol extract, concentrate under reduced pressure to remove the solvent, disperse the concentrate with a small amount of distilled water, and process the The HP-20 type macroporous adsorption res...

Embodiment 3

[0034] 10kg of dried whole herb of ghost needle grass, reflux extraction with 10 times the amount of 80% ethanol for 3 times, each time for 1.5h, filter, combine the filtrate, concentrate the filtrate under reduced pressure, until the ethanol content in the liquid is about 5%, the liquid The concentration is about 0.70g per milliliter of the whole herb containing ghost needle grass, put it in a cold place for 24 hours, precipitate the insoluble matter, centrifuge, discard the precipitate, extract and degrease the supernatant with petroleum ether (1 / 2 the volume of the medicine solution x 3 times), and the medicine solution Concentrate under reduced pressure to remove the residual organic solvent, then extract with a 4:1 water-saturated n-butanol-ethyl acetate mixed solvent until the color of the extract becomes lighter, combine the mixed solvent extracts, and concentrate under reduced pressure to remove the solvent , the concentrated solution was dispersed with a small amount o...

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Abstract

The invention discloses a preparation method of spanishneedles herb total flavonoids, which can be obtained by the following steps: the spanishneedles herb is extracted through ethanol reflux; minimum quantity of ethanol is recovered, impurities are removed by standing and organic solvent is used for defatting; then mixed solvent is extracted beneficiation and resin purification, thus spanishneedles herb total flavonoids is obtained. The obtained flavone extract has high flavone content, over 50%. With simple and feasible technique, and high extract yield rate, the invention is suitable for industrialized production. The total flavonoid extract obtained from the invention has the effect of reducing blood pressure, blood lipid and blood sugar, anti-oxidation and preventing hepatic fibrosis, which can prepare drugs for treating cardiovascular diseases, reducing blood pressure, blood lipid and blood sugar as well as preventing haptic fibrosis.

Description

technical field [0001] The invention relates to a preparation method of the active ingredient of P. punctatus, belonging to the field of preparation of active ingredients of natural medicines. Background technique [0002] Ghost needle grass is a plant of the family Compositae (Comppositae). In East China, Southwest China, Shaanxi, Gansu and other places, it grows on roadsides, wastelands, hillsides and fields. "Dictionary of Traditional Chinese Medicine" records that "Ghost needle grass tastes bitter and flat, non-toxic, clears heat and detoxifies, dispels blood stasis and reduces swelling, and is mainly used for malaria, diarrhea, dysentery, acute nephritis of hepatitis, stomach pain, intestinal fistula, sore throat, traumatic injuries Injuries, snake bites, etc." Guizhencao can be used to treat colds, goiter, chronic pelvic inflammatory disease, uterine prolapse, neurasthenia, etc.; its preparation, Yuenian Tablet, has a good effect on essential hypertension; it is used...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P3/06A61P9/12
Inventor 张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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