Oral cavity rapid release preparation and method for preparing the same

Abstract

The invention discloses an oral quick-releasing medicament and a process for preparation, raw materials of the invention comprise drugs and findings, the weight ratios of the raw materials are that drugs 5 to 85 parts and the findings is oiliness disperser 15 to 95 parts, and the medicament takes solid shape. Getting raw materials to be standby according to the raw material parts and the weight ration, and the raw materials are made into paper stock by adopting a mode of grinding and stirring, fineness in paper stock is that paper stock which is 95% weight of the medicament can flow in 20 DEG C to 60 DEG C, and the medicament of the invention is prepared through adopting a cooling and shaping method or a powder forming method. An active effect of the invention mainly reflects in that since the preparation of the invention adopts the oiliness disperser and reasonable proportional relationship of each part and the like, the preparation of the invention improves dispersion rate of drugs ingredients in orals, the invention improves absorption rate of drugs under the premise of rapid disintegration, dissolution, and fast effect. When oral saliva is hyposecretion, the phenomenon that medicament is adhered on oral membrane can be avoided, uncomfortable feelings can not occur under any circumstances.

Description

technical field [0001] The invention relates to medicine, which is an oral quick-release preparation and a preparation method thereof. Background technique [0002] Because the medicine of the oral immediate release preparation does not need water to be taken, and is easy to meet the saliva in the oral cavity, it provides a better way of oral medicine for patients with poor swallowing function or inconvenient water intake. This field has high requirements for such agents: rapid disintegration and dissolution, fast onset of action, improved absorption and bioavailability of drugs, and at the same time, reduced stimulation of drugs on the esophagus and gastrointestinal tract. However, at present, these commercially available medicaments have many shortcomings: the solubility after disintegration is not good, and the grainy feeling is obvious; when the saliva secretion is insufficient, the preparation is often adhered to the oral membrane, causing a strong sense of discomfort, ...

AI Technical Summary

Problems solved by technology

However, at present, these commercially available medicaments have many shortcomings: the solubility after disintegration is not good, and the grainy feeling is obvious; when the saliva secretion is insufficient, the preparation is often adhered to the oral membrane, causing a strong sense of discomfort, and Affects the speed of onset of action; due to the complicated manufacturing method of the preparation, the excessive water absorption is difficult to preserve, so that the strength of the preparation is low; because the quick release of the preparation is inversely proportional to the strength of the tablet, it is difficult to achieve the ratio of the excipients and the main drug good unity etc.