Patch of carsick-prevention containing anisodine component

Abstract

The invention discloses a paster for treating motion sickness, belonging to drugs for treating nausea, motion sickness or vertigo. The preparation is composed of five layers: a protective layer, a mucilage layer, a controlled release film layer, a drug storage cavern layer and a backing layer. The components of the preparation are that: the drug storage cavern layer contains 10 percent to 50 percent of anisodine, 0 percent to 20 percent of transdermal enhancer, and the other component is water-soluble or water insoluble matrix; the mucilage layer contains 0 percent to 30 percent of the anisodine, 2 percent to 20 percent of the transdermal enhancer, and the other component is pressure sensitive adhesive; the backing layer is PET or non-woven fabric; the protective layer is PET film processed to antistick; and the controlled release film film is EVA polymer film. The total area of the paster is 1 square centimeters to 5 square centimeters, and each tablet contains the anisodine for 3 mg to 15 mg. The invention has obvious effect to treat carsickness, is convenient to be used, and does not have the disadvantages of the oral drugs; and the drug release in vitro of the invention reaches zero order rate process.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating nausea, motion sickness or vertigo, in particular to a patch for preventing and treating motion sickness containing anisodine. Background technique [0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by various reasons such as swinging, bumping, rotating, and accelerated motion. The disease often occurs after a few minutes to several hours of riding, sailing, flying and other operations. At the beginning, I felt epigastric discomfort, nausea, pale complexion, and cold sweats, followed by dizziness, depression, increased salivation, and vomiting. There may be a drop in blood pressure, deep and slow breathing, and nystagmus. Severe vomiting causes fluid and electrolyte disturbances. Symptoms generally disappear or lessen within tens of minutes or hours after stopping or slowing down. It also gradually recovers after several day...

AI Technical Summary

Problems solved by technology

However, the therapeutic index of this drug is relatively small. If the dose is increased, the blood concentration will be too high, and side effects such as dry mouth, diplopia, and even central nervous system depression will occur.

Generally, motion sickness medicine is taken orally, because of the peak-valley phenomenon, the side effects are more obvious

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