Antitussive solution preparation for inhalation and preparation method of solution preparation

A preparation and solution technology, applied in the field of pharmacy, can solve the problems of difficult swallowing, poor patient compliance, long disintegration time, etc., and achieve the effects of avoiding the first-pass effect, high drug concentration, and no toxic side effects

Pending Publication Date: 2020-01-03
INCREASEPHARM HENGQIN INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. The original medicinal materials are used orally, and the supplementary materials added to the tablet are relatively large in volume, and the oral dosage form needs to go through the first-pass effect of the liver, enter the circulatory system and act on the patient's site, the onset of effect is slow, and the patient's compliance is poor;
[0006] 2. Sugar-coated tablets are compressed and formed, which take a long time to disintegrate and dissolve slowly, and are prone to moisture, cracking, and discoloration. At the same time, sugar-coated tablets are not suitable for the elderly and diabetics;
[0007] 3. Children, coma and vomiting patients are not easy to swallow
There is no special preparation for inhalation cough solution in the prior art, and it will have a good market prospect

Method used

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  • Antitussive solution preparation for inhalation and preparation method of solution preparation
  • Antitussive solution preparation for inhalation and preparation method of solution preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Cough solution for inhalation 1000ml:

[0042] Baibu 100g

[0043] Peucedanum 106g

[0044] Bitter almonds 80g

[0045] (1) Weigh the raw materials Baibu, Peucedanum, and Bitter Almond according to the prescription ratio;

[0046] (2) Take a hundred parts, add 8 times the amount of water for the first time, decoct for 1.5 hours, add 8 times the amount of water for the second time, decoct for 1.5 hours, filter, combine the filtrates, concentrate to 1ml containing 5g of crude drug, add ethanol to contain Alcohol content 70%, stir well, stand still for 24h, recover ethanol after filtration until 1ml contains 4g crude drug, add water until 1ml contains 1g crude drug, let stand for 24h, filter; concentrate until 1ml contains 5g crude drug, add ethanol to alcohol content 85% %, stir well, let stand for 12 hours, recover ethanol after filtration until 1ml contains 10g crude drug, add water until 1ml contains 1g crude drug, pass through macroporous resin column, wash with wa...

Embodiment 2

[0051] Cough solution for inhalation 1000ml:

[0052] 100 120g

[0053] Pedicure 135g

[0054] Bitter almonds 90g

[0055] (1) Weigh the raw materials Baibu, Peucedanum, and Bitter Almond according to the prescription ratio;

[0056] (2) Take a hundred parts, add 8 times the amount of water for the first time, decoct for 2 hours, add 8 times the amount of water for the second time, decoct for 1 hour, filter, combine the filtrate, concentrate to 1ml containing 4g crude drug, add ethanol to the alcohol content 70%, stir well, stand still for 12 hours, recover ethanol after filtration until 1ml contains 4g crude drug, add water until 1ml contains 3g crude drug, let stand for 24h, filter; concentrate until 1ml contains 5g crude drug, add ethanol until the alcohol content is 85%, Stir well, let stand for 12 hours, recover ethanol after filtration until 1ml contains 8g crude drug, add water until 1ml contains 0.5g crude drug, pass through macroporous resin column, wash with water...

Embodiment 3

[0061] Cough solution for inhalation 1000ml:

[0062] 100 165g

[0063] Pedicure 185g

[0064] Bitter almonds 105g

[0065] (1) Weigh the raw materials Baibu, Peucedanum, and Bitter Almond according to the prescription ratio;

[0066] (2) Take a hundred parts, add 8 times the amount of water for the first time, decoct for 2 hours, add 10 times the amount of water for the second time, decoct for 1.5 hours, filter, combine the filtrate, concentrate to 1ml containing 3g of crude drug, add ethanol to contain alcohol Amount of 70%, stir well, stand still for 12h, recover ethanol after filtration until 1ml contains 3.5g crude drug, add water until 1ml contains 0.6g crude drug, let stand for 24h, filter; concentrate until 1ml contains 4g crude drug, add ethanol to alcohol content 90%, stir well, let stand for 12h, recover ethanol after filtration until 1ml contains 11g crude drug, add water until 1ml contains 1.5g crude drug, pass through macroporous resin column, wash with water,...

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Abstract

The invention relates to an antitussive solution preparation for inhalation and a preparation method of the solution preparation, and belongs to the field of manufacturing pharmacy. The solution preparation comprises the effective components of three raw materials of traditional Chinese medicine radix stemonae, peucedanum roots and bitter almonds, and auxiliary materials. Compared with the prior art, the antitussive solution preparation for inhalation provided by the present invention rapidly forms an aerosol through an atomizer, directly and quickly acts on an affected part, has quick effect,does not contain preservatives and has no toxic or side effects; and at the same time, first-pass effects and gastrointestinal degradation are avoided, the concentration of the drug at the nidus is increased, the dosage is reduced, the distribution of the drug in other tissues is reduced, the side effects of the drug are reduced, and the use is safer.

Description

technical field [0001] The invention relates to an antitussive solution preparation for inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Cough tablets are classic Chinese patent medicines, which are recorded in Volume 4 WS3-B-0700-91 of the Ministry of Health Drug Standards (Prescriptions of Traditional Chinese Medicine) of the People's Republic of China. [0003] Cough Zhi Tablets are mainly used for moistening the lungs and relieving asthma, eliminating phlegm and relieving cough, and are used for cough, excessive phlegm and asthma. The prescription consists of three medicinal materials: Baibu, Peucedanum, and Bitter Almond. Baibu is warm but not cold, and is used to treat cough and phlegm caused by cold air; Peucedanum is bitter and slightly cold, reducing qi and reducing phlegm, dispersing wind and clearing heat; bitter almond is bitter and slightly warm, used for coughing and asthma, chest fullness and phleg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/12A61K47/26A61K36/904A61P11/00A61P11/10A61P11/14
CPCA61K9/0073A61K47/26A61K36/904A61K36/23A61K36/736A61P11/00A61P11/14A61P11/10A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 张保献胡杰王志华李文慧
Owner INCREASEPHARM HENGQIN INST CO LTD
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