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Asarone-containing patch and preparation method thereof

The technology of Xinnao patch and Asarum, which is applied in directions such as pharmaceutical formulations, medical preparations of inactive ingredients, and sheet-like transportation, can solve the problems of poor reconstitution effect of freeze-dried powder injection, difficult product quality assurance, and preparation process. Complex process and other problems, to avoid toxic effects, avoid first-pass effect, and maintain the effect of blood drug concentration

Active Publication Date: 2018-05-25
FERGUSON WUHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Asarone is insoluble in water, and it is generally necessary to add a lot of solubilizing agents to make injections, such as Tween 80, etc., and the side reactions of injections are many, and the product quality is difficult to guarantee
The reconstitution effect of freeze-dried powder injection is relatively poor, and the preparation process is complicated

Method used

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  • Asarone-containing patch and preparation method thereof
  • Asarone-containing patch and preparation method thereof
  • Asarone-containing patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A patch containing asarum, the formula consists of the following ingredients:

[0042] Drug storage layer (1000 stickers):

[0043]

[0044] Made: 1000 patches, each patch dose 15g.

[0045] The preparation method is as follows:

[0046] Disperse carbomer in purified water for 12 to 24 hours in a stirring tank, dissolve ethylparaben in propylene glycol and add to the stirring tank, then dissolve aluminum trichloride and citric acid with an appropriate amount of purified water and add to the In the stirring tank, add micronized asarone (D90 less than 20 μm), mono- and diglycerin stearate, Tween 80, and glycerin into the stirring tank, turn on the stirring paddle, and stir for 20 minutes. Then add triethanolamine and stir evenly, control the pH between 5.8 and 6.2, then vacuumize to remove air bubbles, and maintain the vacuum degree at <25Pa. Spread the prepared gel on the non-woven fabric, cover it with an adhesive layer, and cut it into a patch of suitable size ac...

Embodiment 2

[0048] A patch containing asarum, the formula consists of the following ingredients:

[0049] Drug storage layer (1000 stickers):

[0050]

[0051]

[0052] Made: 1000 patches, each patch dose 15g.

[0053] The preparation method is as follows:

[0054] Disperse carbomer and sodium polyacrylate 7S in purified water for 12 to 24 hours in a stirring tank, dissolve methylparaben and propylparaben in propylene glycol, and then add aluminum trichloride and lemon Dissolve the acid with an appropriate amount of purified water and add it to the mixing tank, then add micronized asarone (D90 less than 20 μm), mono- and diglycerin stearate, Tween 80 and glycerin into the mixing tank, and turn on the stirring paddle , stirred for 20min. Then add triethanolamine and stir evenly, control the pH between 5.8~6.2, then vacuumize to remove air bubbles, and maintain the vacuum degree at <25Pa. Spread the prepared gel on a non-woven fabric, cover with an adhesive layer, and cut it into ...

Embodiment 3

[0056] A patch containing asarum, the formula consists of the following ingredients:

[0057] Drug storage layer (1000 stickers):

[0058]

[0059] Made: 1000 patches, each patch dose 15g.

[0060] The preparation method is as follows:

[0061] Disperse sodium carboxymethylcellulose and sodium polyacrylate 7S in purified water for 1 to 2 hours in a stirring tank, then dissolve potassium sorbate, aluminum trichloride and citric acid with an appropriate amount of purified water and add them to the stirring tank , and then add micronized asarone (D90 less than 20 μm), mono- and diglyceride stearate, Tween 80, and glycerin into the stirring tank, turn on the stirring paddle, and stir for 20 minutes. Adjust the pH value, control the pH between 5.8 and 6.2, and stir evenly. Then vacuumize to remove air bubbles, and maintain the vacuum at <25Pa. Spread the prepared gel on a non-woven fabric, cover it with an adhesive layer, and cut it into a patch of an appropriate size accord...

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Abstract

The invention discloses an asarone-containing patch, and relates to the technical field of pharmaceutic preparations. The asarone-containing patch is cataplasm. By mass parts, the asarone-containing patch is prepared from 1 part of asarone, 3 to 5 parts of an auxiliary penetrant and 94 to 96 parts of a matrix. According to the asarone-containing patch disclosed by the invention, by the adding of the auxiliary penetrant, the asarone is relatively high in skin transmittance rate, and the transmittance rate can be maintained at zero-order release. The shortcoming of low injection compliance is overcome. The asarone-containing patch only needs to be stuck to the forehead or other skin positions to realize cooling and defervescence; meanwhile, the asarone-containing patch is obviously better than granules or mixed suspension oral liquid, can avoid the first-pass effect of liver and gastrointestinal stimulation reactions, and has the characteristics of a definite curative effect, stable quality, high safety and a small side effect. The invention discloses a preparation method of the asarone-containing patch.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a patch containing asarone and a preparation method thereof. Background technique [0002] The main component of asarone is α-asarone, which is the main active ingredient of the traditional Chinese medicine Shichangpu. Asthma: This product can resist histamine, acetylcholine, and relieve bronchospasm; Cough: It has a strong inhibitory effect on the cough center; expectorant: This product can increase airway secretions and dilute sputum; Sedation: Can significantly reduce Spontaneous activity without inhibition; antispasmodic: similar to aminophylline, it has the effect of relaxing bronchial smooth muscle; anticonvulsant: a~asarone can increase the point stimulation threshold of cerebral cortex, inhibit the synaptic conduction of electrical stimulation and epileptic discharge , has a significant effect on grand mal seizures. [0003] Its structural formula is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/09A61K47/32A61P11/00A61P11/14A61P11/10A61P11/06
CPCA61K9/7061A61K31/09
Inventor 刘欣黄飞赵小伟
Owner FERGUSON WUHAN BIOTECH
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