Nanoparticulate and controlled release compositions comprising aryl-heterocyclic compounds
A composition, nanoparticle technology for use in compositions for psychiatric disorders, controlled delivery of aryl-heterocyclic pharmaceutical compounds, prevention and treatment of schizophrenia and similar psychiatric disorders, field of compositions of ziprasidone , which can solve the problems of poor water solubility and poor bioavailability
Inactive Publication Date: 2008-08-13
ELAN PHRMA INT LTD
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- Abstract
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Problems solved by technology
This poor water solubility results in poor bioavailability
Method used
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Embodiment 1
[0178] Exemplary nanoparticles
Embodiment 2
[0180] Exemplary nanoparticles
Embodiment 3
[0182] Exemplary nanoparticles
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The present invention provides a composition comprising ziprasidone useful in the treatment and prevention of schizophrenia and similar psychiatric disorders. In one embodiment, the composition comprises nanoparticulate particles comprising ziprasidone and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. In another embodiment, the composition comprises a modified release composition that, upon administration to a patient, delivers ziprasidone in a bimodal, multimodal or continuous manner. The invention also relates to dosage forms containing such compositions, and to methods for the treatment and prevention of schizophrenia and similar psychiatric disorders.
Description
field of invention [0001] The present invention relates to compositions useful in the prevention and treatment of schizophrenia and similar psychiatric disorders. In particular, the invention relates to compositions comprising aryl-heterocyclic pharmaceutical compounds, such as ziprasidone. In one aspect of the invention, the composition is in the form of nanoparticles and also comprises at least one surface stabilizer. In another aspect, the invention also relates to novel dosage forms for the controlled delivery of aryl-heterocyclic pharmaceutical compounds, such as ziprasidone, and methods of preventing and treating schizophrenia and similar psychiatric disorders. Background of the invention [0002] Ziprasidone, the chemical name is 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-di Hydrogen-2H-indol-2-one, a benzothiazolylpiperazine derivative, is used as an antipsychotic agent in the treatment of psychiatric disorders such as schizophrenia, halluc...
Claims
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IPC IPC(8): A61K9/64
Inventor J・德韦恩P・斯达克N・范宁G・瑞凯S・简金斯G・里弗斯德格
Owner ELAN PHRMA INT LTD
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