Pharmaceutical combination for curing dysmenorrheal, preparation and quality control method

A composition and medicine technology, applied in the fields of pharmaceutical compositions and preparation methods and quality control, can solve the problems of organ lesions, obvious side effects, body drug resistance and addiction, etc.

Active Publication Date: 2008-09-03
北京富国堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicine such as analgesia is mostly used in the treatment of dysmenorrhea. Long-term monthly medication will not only easily cause drug resistance and addiction in the body, but also cause lesions in the liver, kidney, stomach and other organs, with obvious side effects

Method used

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  • Pharmaceutical combination for curing dysmenorrheal, preparation and quality control method
  • Pharmaceutical combination for curing dysmenorrheal, preparation and quality control method
  • Pharmaceutical combination for curing dysmenorrheal, preparation and quality control method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 2

[0058] Experimental Example 2 Writhing Reaction Experiment of Mice Induced by Glacial Acetic Acid

[0059] Get 50 healthy mice with a body weight of 18-22g, and randomly divide them into 3 groups. Group A is subcutaneously injected with normal saline 0.1ml / 10g; Group B is fed with Tongjingbao granule 0.15ml / 10g; 0.15ml / 10g (1ml contains 5g of the original drug); 0.1ml / 10g of 0.7% glacial acetic acid was injected intraperitoneally after subcutaneous administration for 15 minutes and gavage for 20 minutes. Observe and record the number of times the mice writhe within 20 minutes, and the results are shown in Table 2:

[0060] Table 2 Inhibition of writhing response in mice

[0061] group

dosage

(ml / 10g)

writhing reaction number

First

0.1

46.5±12.3

[0062] Second

0.15

7.4±3.1

C

0.15

4.1±4.3

[0063] Note: P<0.01 between blank group A and groups B and C, and P<0.05 bet...

experiment example 3

[0065] Experimental Example 3 Effects on Rat Uterus in Vivo

[0066] Take 20 healthy non-pregnant female rats and divide them into two groups. Before the experiment, inject diethylstilbestrol subcutaneously at 0.2mg / 100g, once a day. After 3 days of injection, intraperitoneally anesthetize with pentobarbital sodium, and lie supine on the experiment table for laparotomy. , find one side of the uterine horn, suture the vaginal end and ovarian end of the uterine horn to the fulcrums at the bottom of the special fixed cover, sew a thin thread in the middle of the uterine horn, connect the traction line to the sensor through a pulley, and then sew the abdominal wall Suture around the bottom of the fixed hood, and close the abdominal cavity to record the experimental process through the MS-302 multimedia biological signal recording and analysis system.

[0067] Get above-mentioned rat and inject Rockwell nutrient solution 10ml into peritoneal cavity, tracing normal contraction curve...

experiment example 4

[0071] Experimental example 4 Effect of drugs on isolated uterine smooth muscle under the action of PGF2a analogs or oxytocin

[0072] Select 40 healthy non-pregnant female rats and divide them into 5 groups. Diethylstilbestrol was subcutaneously injected with 0.2mg / 100g before the experiment, once a day. Place it in a small tank filled with 30ml Rockwell solution, connect it to the sensor, keep it in a water bath at (36±0.5)°C, let oxygen flow into the tank from the ventilation hook, and record it with the MS-302 multimedia biological signal recording and analysis system Normal contraction curve, then add cloprostenol (PGF 2a Analogue) 5ug / 0.5ml or oxytocin injection 0.5ug / 5ml, make the uterine smooth muscle contract strongly, add pharmaceutical composition granule 0.6ml of the present invention and Tongjingbao granule 0.6ml after stabilization, observe and record 10min uterine The tension and frequency of smooth muscle contraction, the results are shown in Tables 4 and 5: ...

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Abstract

The invention discloses a pharmaceutical composition for the treatment of dysmenorrheal, a preparation method and a quality control method. The pharmaceutical composition is composed of pharmaceutical raw materials of danshen root, red paeony root, nutgrass galingale rhizome, rose, cattail pollen, yanhusuo (vinegar processed), trogopterus dung, cassia twig, peach seed and costustoot; the preparation method comprises the steps that the pharmaceutical raw materials of the composition are taken, the conventional auxiliary materials are added, a clinically acceptable formulation is prepared according to the conventional process, including but not limited to a concentrated pill, a capsule, a dropping pill, a granule, a tablet, a soft capsule, a sustained release preparation, an oral liquid preparation or a freeze-dried powder injection. The invention adopts the high performance liquid chromatography for carrying out the content determination of paeoniflorin. The pharmaceutical composition of the invention has very good efficacy for the treatment of the dysmenorrheal.

Description

field of invention [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a pharmaceutical composition for treating dysmenorrhea, a preparation method and a quality control method. Background technique [0002] Dysmenorrhea refers to pain in the lower abdomen or lower back of a woman, even reaching the lumbosacral area, before and after menstruation. It often occurs with the menstrual cycle. In severe cases, it may be accompanied by nausea and vomiting, dripping cold sweat, cold hands and feet, and even fainting, which will seriously affect work and life. At present, it is often divided into primary and secondary clinically. Primary dysmenorrhea refers to those without obvious lesions in the reproductive organs, so it is also called functional dysmenorrhea. It is more common in adolescent girls, unmarried and married without children. The reasons are mostly mental stress and hypersensitivity; weaker ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P15/00A61P29/00G01N30/90G01N30/02A61K35/24
Inventor 付立家付建家
Owner 北京富国堂医药科技有限公司
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