Method for activation treatment of antigen-presenting cell
A technology for activation treatment and cells, applied in biochemical equipment and methods, receptors/cell surface antigens/cell surface determinants, antibacterial drugs, etc.
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no. 1 approach
[0063] First Embodiment: Production of Activated Antigen Presenting Cells
[0064] First, the activated antigen-presenting cells of the present invention will be described in detail.
[0065] The activated antigen-presenting cells of the present invention refer to antigen-presenting cells co-sensitized with a bisphosphonic acid compound and a disease antigen.
[0066] The antigen-presenting cells used in the present invention are not particularly limited, and for example, any of immature dendritic cells, mature dendritic cells, other antigen-presenting cells, artificial antigen-presenting cells, and mixtures thereof can be used. Among them, immature dendritic cells and mature dendritic cells are preferred, and immature dendritic cells are more preferred. This is due to the fact that immature dendritic cells may be better suited to induce disease antigen-specific CTLs and / or γδ T cells when co-sensitized with bisphosphonates and disease antigens. In addition, the aforementi...
no. 2 approach
[0097] Second Embodiment: Drugs Containing Activated Antigen Presenting Cells of the Present Invention
[0098] Next, the drug using activated antigen-presenting cells of the present invention will be described based on an example of using dendritic cells as antigen-presenting cells in the same manner as above.
[0099] First, the activated antigen-presenting cells (activated dendritic cells) obtained in the first embodiment described above are recovered by centrifugation or the like. Next, the recovered cells are washed. As the washing liquid, any liquid can be used as long as it is isotonic and can be used as a medicine. Thereafter, in consideration of administration to patients, physiological saline, PBS, and the like are preferably used. Furthermore, the recovered dendritic cells can be used as medicines by suspending them in physiological saline. In addition, serum components such as albumin or cytokines may be added as needed. In particular, the drug is preferably ...
no. 3 approach
[0100] Third Embodiment: Therapeutic and preventive methods using activated antigen-presenting cells of the present invention Law
[0101] Next, the method of treatment and prevention using dendritic cells of the present invention will be described based on an example of using dendritic cells as antigen-presenting cells in the same manner as above.
[0102] Cancer and / or infectious diseases can be treated and prevented by administering the activated antigen-presenting cells (activated dendritic cells) of the present invention obtained in the first embodiment above or the drug of the present invention obtained in the second embodiment.
[0103] The number of cells to be administered can be appropriately selected according to the method of administration and the condition of the patient, and is not particularly limited. Usually each dose is preferably 10 6 ~10 8 person / person, more preferably 10 7 One / person or more. The frequency of administration varies depending on th...
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