Diheterocycle compound containing 4-thiazolidinone and pyrimidine, synthetic method and application thereof

Abstract

The invention discloses a compound containing 4-thiazolinedione and pyrimidine diheterocycle, as well as a synthesis method and an application thereof. The method includes the following steps: firstly under the action of an acid reagent, an adequate reaction is carried out between 2-methylthio-4-amino-5-aldehyde pyrimidine and the 4-substituted-aminothiourea shown in formula (II) in an organic solvent A under the action of acid at circumfluence temperature, and then the reaction liquid undergoes a treatment to obtain thiosemicarbazone shown in formula (III); secondly, under the action of an alkali reagent, the thiosemicarbazone obtained in step one reacts with a cyclization reagent with the structure of X-CH2COOR' in an organic solvent B at the circumfluence temperature, and then the reaction liquid undergoes a treatment to obtain the compound containing 4-thiazolinedione and pyrimidine diheterocycle shown in formula (I). The compound containing 4-thiazolinedione and pyrimidine diheterocycle shows certain inhibitive effect against one or a plurality of plant pathogenic bacterium, and can be used as the bactericide.

Description

(1) Technical field The invention relates to a biheterocyclic compound containing 4-thiazolidinone and pyrimidine, a synthesis method and application thereof. (2) Background technology Heterocyclic compounds are the main research direction for the development of new pesticides. Among heterocyclic compounds, thiazole compounds are an important class. Currently, many commercialized fungicides, insecticides and herbicides belong to this class of compounds. For example, flufenoxil developed by Bayer Company of Germany is an acaricide, which is effective against P. ulmis and Tetranychus pests; Rice blast caused by pear spores is effective. 4-thiazolidinone derivatives have a wide range of biological activities and can be used in the fields of medicine and pesticides. For example, thiafencarb, the international common name tazimcarb, is exactly a kind of good acaricide; Domestic Shen Jianhua (CN1699354) etc. have revealed that a class of 2,3,5-trisubstituted-4-thiazolidinone de...

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Problems solved by technology

However, there are no literature reports on the synthesis and biological activity of biheterocyclic compounds containing 4-thiazolidinone and pyrimidine

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