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Method for purifying blood and blood products

A blood product and blood technology, applied in blood diseases, chemistry, extracellular fluid diseases, etc., can solve problems such as inability to remove viruses, and achieve the effects of no dye residue, strong specificity, and easy operation

Active Publication Date: 2008-10-01
西安血氧生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The purpose of the present invention is to provide a method for purifying blood and blood products, which solves the technical problem that the inactivated virus cannot be completely removed from blood or blood products in the background technology

Method used

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  • Method for purifying blood and blood products
  • Method for purifying blood and blood products

Examples

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Embodiment 1

[0037] Example 1: Add 3mg of phenothiazine dye-modified magnetic particles to 200ml of blood in a clinical bag, irradiate with 660nm wavelength light for 20 minutes, place the blood bag in a 3000 Gauss strong magnetic field, and precipitate the magnetic particles to achieve Separation from blood. The purified blood can be directly used for clinical transfusion.

Embodiment 2

[0038] Example 2: 0.2 g of phenothiazine dye-modified magnetic particles were added to every 15 liters of blood or blood products. The magnetic separation device uses a slender transparent cylindrical container with a diameter of 20 cm and a volume of 20 liters to be fixed on the support. The two ends of the container are provided with a liquid inlet port and an outflow port. There are several lamps that can generate light with a wavelength of 600-700 nm on the outer periphery of the cylindrical container. Tube. The mixture of blood or blood products and phenothiazine dye-modified magnetic particles is introduced into the magnetic separator, and slowly flows through the magnetic separation device. The cylindrical container is slowly rotated around the axis driven by the motor, and the temperature is room temperature for 30 minutes. The purified blood can be directly canned into blood bags for storage in blood banks or directly used for clinical transfusion.

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Abstract

The invention relates to a method for purifying blood and blood products, which takes a phenothiazine dye modified magnetic particle as a solid-phase carrier for reaction and separation, a magnetic sphere is added and evenly mixed according to the ratio that 5 to 50mg phenothiazine dye modified magnetic particle added into each liter of blood or blood product to be processed, then the virus is absorbed on the phenothiazine dye modified magnetic particle, light with the wavelength of 600 to 800nm is used for radiation, thus activating the phenothiazine dye which is bonded on the surface of the phenothiazine dye modified magnetic particle, the generated singlet oxygen and hydroxyl radical can kill the virus, an external magnetic field is used for separating the mixture of the phenothiazine dye modified magnetic particle and the blood or the blood product of the killed virus, thus obtaining the purified blood or the blood product. The method for purifying blood and blood products of the invention can solve the technical problem that the virus after the inactivation cannot be completely removed from the blood or the blood products in the background technology, and has strong specificity, no residual dye and convenient operation.

Description

technical field [0001] The invention relates to a method for purifying blood and blood products, in particular to a method for killing and removing viruses in blood and blood products by using magnetic particles modified with phenothiazine dyes. Background technique [0002] Blood transfusion is an effective means of treatment to save lives, but blood transfusion is also accompanied by the risk of transmission of viral diseases such as AIDS, hepatitis B and hepatitis C. According to statistics, the number of people infected with HIV (HIV) in the world is more than 30 million, the number of people infected by hepatitis B virus (HBV) is about 370 million, the number of people infected by hepatitis C virus (HCV) is about 180 million, and the number of people infected by HIV 5-10% of the total stems from unsafe blood transfusions! [0003] At present, the treatment of viruses contained in blood and blood products mainly includes inactivation and removal. [0004] Among the ina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61P7/00A61L2/16A61L101/40
Inventor 高文运陈超
Owner 西安血氧生物技术有限公司