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Duanxueliu extract oral freeze-dried tablet and preparation thereof

A technology of extracting and breaking blood flow, which is applied in the field of freeze-dried orally disintegrating tablets of traditional Chinese medicine cutting blood flow extract and its preparation, can solve problems such as complex process, not the best effect of masking taste, uncomfortable odor, etc., and achieve moisture resistance The effect is good, the technical method is simple and practical, and the effect of improving work efficiency

Inactive Publication Date: 2008-11-12
海南高升医药科技开发股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Orally disintegrating tablets are oral dosage forms that disintegrate completely in the mouth, which requires covering up the bad taste of the medicine in the mouth, but most medicines have unpleasant odors, especially traditional Chinese medicines. Unacceptable bitterness, in the field of pharmaceutical preparations, mainly achieves the effect of drug taste masking through the following two methods, the first is mainly to obtain a good mouthfeel (i.e. flavoring) by adding sweeteners or essences; and For drugs with heavy bitterness, adding sweeteners or flavors alone cannot completely cover up the bitterness of the drug. At home and abroad, the drug is mainly coated or encapsulated to achieve a good effect (i.e. taste masking), such as β- Methods such as cyclodextrin inclusion, solid dispersion technology, film particle coating or adding flavoring agents to the composition, and the final product must also be verified, such as X-diffraction, differential thermal analysis (DSC), etc., the process is complicated , and the taste masking effect is not the best

Method used

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  • Duanxueliu extract oral freeze-dried tablet and preparation thereof
  • Duanxueliu extract oral freeze-dried tablet and preparation thereof
  • Duanxueliu extract oral freeze-dried tablet and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] See Table 1: The unit composition and percentage composition of the orally disintegrating tablet of the present invention are given

[0033]

[0034] 2. Preparation method

[0035] Step 1: Weigh sodium bicarbonate according to the amount, add an appropriate amount of water, stir and dissolve into a colorless clear liquid.

[0036] Step 2: Weigh the cut off blood flow extract according to the amount, add it to the above solution, stir and dissolve at a temperature of 70°C to 85°C to form a dark red liquid, and cool it for later use.

[0037] Step 3: Weigh the mannitol, gelatin and aspartame according to the amount, add an appropriate amount of water, stir and dissolve at a temperature of 50°C to 70°C to form a colorless clear liquid, and cool it for later use.

[0038] Step 4: Wash and combine the cooled third-step solution into the second-step solution, then measure the prepared hydroxypropyl methylcellulose solution according to the amount, add it to the mixed solu...

Embodiment 2

[0048] See Table 2: The unit composition and percentage composition of the orally disintegrating tablet of the present invention are given

[0049]

[0050] 2. Preparation method

[0051] Step 1: Weigh sodium bicarbonate according to the amount, add an appropriate amount of water, stir and dissolve into a colorless clear liquid.

[0052] Step 2: Weigh the cut off blood flow extract according to the amount, add it to the above solution, stir and dissolve at a temperature of 70°C to 85°C to form a dark red liquid, and cool it for later use.

[0053] Step 3: Weigh the mannitol, gum arabic and sucralose according to the amount, add an appropriate amount of water, stir and dissolve at a temperature of 50°C to 70°C to form a colorless clear liquid, and cool it for later use.

[0054] The fourth step: wash the cooled third step solution and merge it into the second step solution, then weigh the acrylic resin (No. IV) according to the amount, add it to the mixed solution to make a...

Embodiment 3

[0064] See Table 3: The unit composition and percentage composition of the orally disintegrating tablet of the present invention are given

[0065]

[0066] 2. Preparation method

[0067] Step 1: Weigh sodium bicarbonate according to the amount, add an appropriate amount of water, stir and dissolve into a colorless clear liquid.

[0068] Step 2: Weigh the cut off blood flow extract according to the amount, add it to the above solution, stir and dissolve at a temperature of 70°C to 85°C to form a dark red liquid, and cool it for later use.

[0069] Step 3: Weigh the lactose, gelatin and sucralose according to the amount, add an appropriate amount of water, stir and dissolve at 50°C to 70°C to form a colorless clear liquid, and cool for later use.

[0070] The fourth step: wash the cooled third step solution and merge it into the second step solution, then weigh the polyacrylic acid resin (No. IV) according to the amount, add it to the mixed solution after grinding to make a...

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Abstract

The invention belongs to the Chinese medicine preparation technical field and provides a chinse clinopodium herb extract oral lyophilisate and a method for preparing the same. The oral lyophilisate is mainly prepared by taking chinse clinopodium herb extract as active ingredient and adding adequate auxiliary materials to prepare solution and through vacuum freeze drying. The chinse clinopodium herb extract oral lyophilisate is good in mouthfeel, quick in disintegration (complete dissolution), convenient in taking and so on.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, and provides a freeze-dried orally disintegrating tablet of a traditional Chinese medicine blood flow extract and a preparation method thereof. Background technique [0002] At present, there are many medicines used for cooling blood and hemostasis clinically. As the most effective and safest clinical drug in this area, Duoxueliu extract tablet has the main function of cooling blood and hemostasis, which is more suitable for functional uterine bleeding and menorrhagia. , postpartum hemorrhage, uterine fibroid hemorrhage, hematuria, hematochezia, hematemesis, epistaxis, idiopathic thrombocytopenic purpura, etc.; also for hereditary telangiectasia, allergic purpura, simple purpura, thrombocytosis and hemophilia All have very good curative effect; According to reports, the pharmacological action of the traditional Chinese medicine Duanxueliu extract tablet is not on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/20A61K47/42A61K47/38A61K47/34A61P7/04A61K47/18A61K47/26
Inventor 王小树杨贵方刘红
Owner 海南高升医药科技开发股份有限公司
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