A method of diagnosis and treatment and agents useful for same
A cell, telomerase technology, used in biochemical equipment and methods, disease diagnosis, biological testing, etc.
Inactive Publication Date: 2008-11-26
MEDVET SCI
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- Description
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Problems solved by technology
This ideal of effectively targeting and killing malignant cells has so far been elusive
Method used
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The present invention relates generally to a method of screening for the level of neoplastic cell death in a subject. More particularly, the present invention provides a method of screening for the level of neoplastic cell death by detecting the level of expression of telomerase protein and / or gene by dead cells in said subject or in a biological sample derived from said subject. The method of the present invention is useful in a range of applications including, but not limited to, assessing a neoplastic condition, monitoring the progression of such a condition, assessing the effectiveness of a therapeutic agent or therapeutic regime and predicting the likelihood of a subject either progressing to a more advanced disease state or entering a remissive state. The present invention also provides diagnostic agents useful for detecting telomerase protein and / or nucleic acid molecules.
Description
field of invention The present invention generally relates to methods of screening for levels of neoplastic cell death in a subject. More specifically, the present invention provides a method for evaluating the level of neoplastic cell death by detecting the level of telomerase protein and / or gene expressed by dead cells in the subject or in a biological sample derived from the subject. Methods. The invention has a wide range of applications including, but not limited to, evaluating neoplastic disease, monitoring the progression of such disease, evaluating the efficacy of a therapeutic agent or treatment regimen, and predicting the likelihood of a subject progressing to a higher disease stage or entering remission . The present invention also provides diagnostic reagents for detecting telomerase protein and / or nucleic acid molecules. The invention also provides a method of therapeutically targeting a drug, such as a cell proliferation inhibitor, in vitro or in vivo. This a...
Claims
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IPC IPC(8): G01N33/574G01N33/53G01N33/577A61K51/10A61K39/395A61P35/00C12Q1/68
CPCG01N33/57488G01N33/5011C07K16/40G01N2800/52G01N33/573A61P35/00A61P35/04A61P37/04G01N33/574G01N33/577A61K51/10G01N33/53
Inventor M·P·布朗
Owner MEDVET SCI
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