Thiophene macrocyclic compound and preparation method for its derivant

Abstract

The invention relates to a thiophene macrocyclic compound and a preparation method of derivatives of the thiophene macrocyclic compound, in particular to a preparation method of a thiophene eight membered cyclic compound and a thiophene twelve membered cyclic compound. The preparation method is as follows: 2, 2`-dibromo-[3, 3`]-bithiophene is adopted as the raw material; lithium diisopropylamide (LDA) is firstly used to capture the Alpha- proton, then the 2, 2`-dibromo-[3, 3`]-bithiophene is quenched by trimethylchlorosilane, and a compound 3 is prepared; then the compound 3 and butyl lithium generate bromine and lithium exchanging reaction, and copper chloride oxidative cyclization is used to generate thiophene eight membered cyclic compound 4 and thiophene twelve membered cyclic compound 5, wherein, the yield of the compound 5 reaches up to 36 percent; and in the condition that trifluoroacetic exists, the compound 4 and the compound 5 remove TMS, and a compound 1-four (2,3-bithiophene) and a compound 2-six (2,3-bithiophene) are obtained. The preparation method of the derivatives of the thiophene macrocyclic compound realizes the aim of preparing the thiophene eight-membered cyclic compound at high yield, and most importantly, the preparation method realizes the aim of preparing the thiophene twelve-membered cyclic compound at high yield, and the total yield of the three steps reaches up to 27 percent. The synthetic process of the method has operability, and the reaction conditions of waterless, oxygen free and low-temperatured. Thus, the preparation method is suitable for scale preparation.

Description

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AI Technical Summary

Benefits of technology

This patented technology allows for efficient production of certain types of chemical substances called beta -thienes such as tenthionine or cathinone by reacting them with specific reactive agents under special circumstances like hydrolysis without water. By adding these reagents together during this step, there will be more stable molecules formed due to their strong interactions between each others. Overall, this new technique provides technical benefits over existing techniques while maintaining its efficiency and effectiveness across various applications.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the efficiency at producing certain types of chemical substances called cyclodimers or cis/transfer dimer systems containing sixteen membered rings. Current processes involve expensive reagents like Grignard Reagent, Lithium Intermediate Exchanger, Fetrilm Group Compound, Diphenol Chelating Ligand Exchange Method, Sulfur Trioxane Cyclotronics Using Microcavity Gravimetrics Technique, Different Technologies were developed overall, these techniques aim to increase production rates while reducing costs associated with current methods.

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