Chinese herbal medicine extract with lipase activity inhibition and new use thereof

An activity-inhibiting, Chinese herbal medicine technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as unclear pharmacological mechanism, unclear active ingredients of Chinese herbal medicine, and inability of Chinese herbal medicine to go to the world.

Inactive Publication Date: 2009-02-11
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to limitations such as unclear active ingredients and pharmacological mechanisms of Chinese herbal medicines, traditional Chinese herbal medicines cannot go to the world. So far, there is no weight-loss drug with independent intellectual property rights in my country.

Method used

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  • Chinese herbal medicine extract with lipase activity inhibition and new use thereof
  • Chinese herbal medicine extract with lipase activity inhibition and new use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: the preparation of Scutellaria baicalensis water extract

[0060] Take Scutellaria baicalensis slices, prefabricate, pulverize; add 5 times the volume of deionized water, boil for 30 minutes, filter, and take the filtrate; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

Embodiment 2

[0061] Example 2: Preparation of Scutellariae Alcohol Extract

[0062] Scutellaria baicalensis slices are taken, prefabricated, and pulverized; 5 times the volume of 75% ethanol is added, ultrasonically extracted for 60 minutes, filtered, and the filtrate is obtained; conventional dosage forms are prepared by conventional methods for the preparation of lipase inhibitors.

Embodiment 3

[0063] Embodiment 3: the preparation of Pu'er tea water extract

[0064] Take Pu'er tea decoction pieces, prefabricate, pulverize; add 10 times the volume of deionized water, boil for 60 minutes, centrifuge at 4000r / min for 20 minutes, and take the supernatant; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

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PUM

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Abstract

The invention discloses a Chinese medicinal herb extract with the function of inhibiting the activity of lipase and the new application thereof. The Chinese medicinal herb extract refers to one of water extract and/or alcohol extract of 61 Chinese medicinal herbs.

Description

technical field [0001] The invention relates to a Chinese herbal medicine extract, in particular to the Chinese herbal medicine extract with lipase activity inhibitory effect and its new application. Background technique [0002] Metabolic syndrome (MS) mainly includes risk factors such as obesity, impaired glucose tolerance, dyslipidemia, and hypertension. The incidence of diabetes (Diabetes mellitus, DM) and cardiovascular disease in MS patients is often several times that of the normal population. MS has seriously endangered human's physical and mental health and has become a worldwide public health problem, but so far our understanding of MS is very limited. Preliminary studies have confirmed that among many causes, obesity has a particularly close relationship with MS, and is a key factor and core link in the onset and development of MS. With the development of economy, the improvement of people's living standard and the change of lifestyle, obesity has become the lar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/9066A61K36/815A61P3/04A61P3/06
Inventor 段震文郭树仁何大林闫雪秋
Owner BEIJING WBL PEKING UNIV BIOTECH
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