Methods of using small molecule compounds for neuroprotection

A technology for small molecular compounds and molecules, which can be used in the active ingredients of heterocyclic compounds, pharmaceutical formulations, organic active ingredients, etc., and can solve the problems of low patient compliance, difficult preparation and implementation, etc.

Inactive Publication Date: 2009-02-11
阿拉巴马大学董事会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing therapeutic options include vaccines and protein therapies, both of which are difficult to prepare and implement
Although these therapies may offer treatment candidates that may not exist, the difficulty of preparation and administration may lead to low patient compliance

Method used

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  • Methods of using small molecule compounds for neuroprotection
  • Methods of using small molecule compounds for neuroprotection
  • Methods of using small molecule compounds for neuroprotection

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Embodiment Construction

[0029] It should be understood that methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All literature, patent applications, patents, and other references mentioned herein are hereby incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, shall prevail. In addition, the materials, methods, and examples are illustrative only and not limiting.

[0030] "Small molecular compound", "candidate compound" and "drug compound" refer to molecular compounds screened for their effects on the formation of active oxygen molecules, protein misfolding and aggregation, neuron damage and neurodegeneration in the present invention. These compounds may include compounds from the Prestwick library, related drug classes, or functional analogs thereof.

[0031] "Protein misfolding" means that a protein folds differently from the normal way that the protein ...

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Abstract

Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application Serial No. 60 / 738,761, filed November 21, 2005, and U.S. Provisional Patent Application Serial No. 60 / 749,910, filed December 12, 2005, both of which are hereby incorporated by reference The entire text is incorporated herein. technical field [0003] The present invention relates to methods and compositions comprising small molecule compounds for protecting neurons from death or degeneration resulting from damage or disease of the central nervous system. Background technique [0004] Disease and impairment of the central nervous system (CNS) can cause devastating and debilitating diseases that change the lives of millions of individuals each year. In general, the evolution of these diseases follows the death and degeneration of neuronal cells leading to mild to severe clinical manifestations of the disease or disorder. Damage from trauma, isc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/497A61K31/44A61K31/43A61K31/00
Inventor 盖伊·A·考德威尔金·A·考德威尔曹嵩嵩
Owner 阿拉巴马大学董事会
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