Novel triterpenoid schisanlactone H and extracting and separating method thereof

A technology for triterpenoids and pentalactones, applied in the field of phytochemistry, can solve the problems of no patents or literature reports on new triterpenoids, and achieve the effects of novel structure, good curative effect, and simple extraction and separation method.

Inactive Publication Date: 2009-03-04
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented chemical can be used effectively against tumor cells or other diseases caused due to their ability to produce bacteriocidal substances that kill them without causing harmful reactions like chemotherapy. It's also being able to make certain types more effective than existing ones while reducing its negative impact on healthy tissues.

Problems solved by technology

This patented problem addressed by these inventors relates to finding novel chemical structures called triterpenols related to certain types of molecules known as phytoalexanes like those produced during traditional Chinese medicine treatments such as tincture extracting, ethanol extraction, etc., but they may be useful against cancerous cell lines without causing harmful side effects on normal healthy ones.

Method used

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  • Novel triterpenoid schisanlactone H and extracting and separating method thereof
  • Novel triterpenoid schisanlactone H and extracting and separating method thereof
  • Novel triterpenoid schisanlactone H and extracting and separating method thereof

Examples

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Embodiment

[0019] Take Schisandra sphenanthera fruit (dry weight 8kg) as raw material, according to the mass / volume ratio of Schisandra sphenanthera: acetone aqueous solution = 1: 3, extract three times with 70% acetone aqueous solution at room temperature, each time for 24 hour, the acetone consumption is 25L * 3, combine three extracts, concentrate under reduced pressure to no acetone smell; press extract: ethyl acetate=1: 1 volume ratio, extract is carried out 3 times with ethyl acetate, recover Obtain 145.9g of extract afterward; After silica gel column chromatography on the extract, use chloroform: acetone respectively: 1: 0, 9: 1, 8:: 2, 7: 3, 6: 4, 5:: 5, 0 : 1 volume ratio eluent, seven gradient elutions were carried out to obtain eight polar sections of A-H respectively, and section B (that is, the part eluted with chloroform: acetone = 9: 1) was successively washed with petroleum ether: acetone = 30 : 1 volume ratio eluent, chloroform: acetone = 50: 1 volume ratio eluent for si...

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Abstract

The invention provides a new triterpene compound (valerolactone H) and an extraction separating method thereof. The new triterpene compound (valerolactone H) is separated from the fruits of orange magnoliavine fruit, has a novel structure, simple extraction separation process and a relatively higher content, facilitates the further pharmacological research thereof and creates the condition for developing novel anti-tumor and anti-HIV pharmaceuticals with good therapeutic effect and low toxic and adverse effects. The new triterpene compound (valerolactone H) has a structural formula as above.

Description

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Claims

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Application Information

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Owner KUNMING UNIV OF SCI & TECH
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