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Medicine composition for preventing and treating AIDS viral infection

A composition and drug technology, applied in antiviral agents, drug delivery, pharmaceutical formulations, etc., can solve the problems of not being able to block the early infection process of HIV, short-term toxic and side effects, etc., and achieve rich intestinal lymphoid tissue, good therapeutic effect and low side effects small effect

Inactive Publication Date: 2009-03-25
张可 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These medicines and methods have the following disadvantages: (1) induce drug-resistant HIV variants; (2) have short-term and long-term toxic and side effects; (3) cannot block the early infection process of HIV
However, there are many candidate drugs for immunotherapy, and there are no related reports on what kind of immunotherapy drugs to choose, what kind of drugs and other drugs to cooperate with each other to form a pharmaceutical composition and its appropriate dosage form to prevent and treat HIV infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Use a special transanorectal mucosal applicator according to the anatomy of the anorectum:

[0030]A 2ml (or 5ml) sterile syringe is used, instead of a needle, a bullet with a smooth tip about 3.5cm in length is used, and the inner diameter is small, which is similar to the inner diameter of a small needle.

[0031] A 2ml (or 5ml) syringe (anorectal applicator) with a bullet tip about 3.5cm long is pre-filled with 1ml of liquid medicine, and injected directly into the rectum through the anus. After the injection, lie in bed for 10 minutes.

Embodiment 2

[0033] One of the ingredients of the composition:

[0034] Contains per ml:

[0035] 1. Recombinant human interleukin-2 (5 million units)

[0036] 2. Chitosan 0.5%, molecular weight 150kD, deacetylation over 85%

[0037] 3. Sodium Glycocholate 1%

[0038] 4. Human Serum Albumin 2%

[0039] 5. Benzyl alcohol 0.5%

Embodiment 3

[0041] Composition two:

[0042] Contains per ml:

[0043] 1. Recombinant human interferon (10 million units)

[0044] 2. Recombinant human interleukin-2 (5 million units)

[0045] 3. Saponin 1%

[0046] 4. Chitosan 0.5%

[0047] 5. Human Serum Albumin 2%

[0048] 6. Benzyl alcohol 0.5%

[0049] 7.40mM phosphate solution buffer its pH5.5

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PUM

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Abstract

The invention relates to pharmaceutical composition for preventing and curing the infection of AIDS virus. The components of the composition comprise at least an immunomodulator-immunologic stimulant, at lest a mucosa sorbefacient, human seralbumin and phenylcarbinol, wherein the immunomodulator-immunologic stimulant is recombined human interleukin, interferon, thymin or Toll sample receptor irritant agent, and the mucosa sorbefacient is surface active agent. The pharmaceutical composition of the invention is prepared to aqua or suppository, alleviates the pain caused by the injection of the immunomodulator-immunologic stimulant; greatly improves the security and validity of the use through nontraumatic administration through the mucosa of rectum, has the treating effect exceeding the subcutaneous injection and muscle injection, and has wide applying and generalizing foreground.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating HIV infection, belonging to the field of pharmaceutical preparations. Background technique [0002] Since the 1980s, Acquired Immunodeficiency Syndrome (also known as AIDS, AIDS) has become a major disease that threatens human health, and the number of cases is increasing year by year. So a famous western medical expert called AIDS "the plague of the century". On December 1, 2003, the "Joint Assessment Report on AIDS Prevention and Control in China" jointly issued by the Ministry of Health of China and the United Nations AIDS China Task Force showed that there are currently about 840,000 HIV-infected people in China, and about 80,000 AIDS patients, distributed in all provinces of the country , autonomous regions, and municipalities directly under the central government, covering all social strata. [0003] At present, anti-AIDS drugs are a hot spot in the field of drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/02A61K9/08A61K47/36A61K47/08A61P31/18A61K38/38A61K38/20A61K38/21A61K38/32
Inventor 张可张丽兰张利萍侯云德
Owner 张可
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