Freeze-dried powder preparation of kuh-seng native, preparation method thereof

A technology of matrine and freeze-dried powder, which is used in freeze-drying transportation, powder transportation, antiviral agent and other directions, can solve the problems of unsatisfactory resolution, affecting the accuracy of content determination, and poor peak shape of spectrum.
CN101428020BActive Publication Date: 2014-03-19HARBIN ZHENBAO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN ZHENBAO PHARMA
Publication Date
2014-03-19

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Abstract

The invention provides a kurarinone freeze-dry powder preparation and a preparation method thereof. The preparation method comprises the following steps: filtering the solution of three components - kurarinone, mannitol, disodium edetate or calcio-sodium edetate in an appropriate proportion, freezing and drying, and then obtaining the freeze-dry powder preparation. Compared with the prior product, the preparation has the advantages that the stability is obviously improved, the expiry date can be as long as 24 months, and the characters of the product are not changed obviously; compared with the prior art, the preparation method is more simplified, and the production cost is saved. The invention also provides a method for detecting the content of oxymatrine in the product of kurarinone freeze-dry powder preparation. By optimizing the mobile phase and the detection condition, a highly-effective liquid-phase chromatographic detection method with better differentiation and stronger specificity is established.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a matrine freeze-dried powder preparation and a preparation and detection method thereof. Background technique

[0002] Sophora flavescens is a perennial herb or shrub, also known as bitter bone, Sichuan ginseng, phoenix claw, and beef ginseng. Bitter is named for its taste, and ginseng is named for its fame, so it is called Sophora flavescens, which is harvested in spring and autumn. The medicinal part of Sophora flavescens is mainly the root, and the alkaloids contained in it are mainly matrine and oxymatrine. Its medicinal value has been recorded as early as in the first Chinese pharmacology book "Shen Nong's Herbal Classic". According to "Compendium of Materia Medica" records: Sophora flavescens, bitter, cold, non-toxic, has the effects of clearing away heat and detoxification, expelling wind and dampness, nourishing the middle and improving eyesight,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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