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Compound Chinese medicine gingko granule and preparation method thereof

A technology of traditional Chinese medicine granules and Ginkgo biloba, which is applied to the traditional Chinese medicine granules of compound ginkgo biloba and the field of preparation thereof, can solve the problems of lack of immediate release properties, low drug loading in the granules, unsightly appearance and the like, and achieves good physical properties, small specific surface area, The effect of regular particle size distribution

Inactive Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1, the preparation of active ingredient of the present invention:

[0046] Preparation of Ginkgo biloba extract: Take 1000g of Ginkgo biloba and crush it, heat and extract 5 times the amount of acetone: water (70:30) mixture twice, each time for 2 hours, at a temperature of 50-60°C, combine the extracts, and filter , concentrated under reduced pressure into 280g of ginkgo leaf extract; preparation of ginseng extract: take 100g of ginseng slices, add 8 times the amount of water, extract twice, each time for 3 hours, combine the extracts, concentrate, and concentrate until each 5ml contains 1g ginseng Medicinal material, 40g of ginseng extract is obtained; Ligusticum chuanxiong is taken, pulverized, and hydrodistilled to obtain 80g of volatile oil of Ligusticum chuanxiong; the above-mentioned extracts are mixed uniformly to prepare the active ingredient of the present invention.

[0047] Preparation of masterbatch: Take the mixture of dextrin and starch with a weight rati...

Embodiment 2

[0050] Preparation of the active ingredient of the present invention: take ginkgo leaves and grind them, add 5 times the amount of 65% ethanol to reflux and extract twice, each time for 2 hours, the temperature is 60 ° C, combine the extracts, filter, concentrate under reduced pressure and recover ethanol to obtain ginkgo leaf extracts Take ginseng slices, add 8 times the amount of 70% ethanol, extract twice, 3 hours each time, combine the extracts, recover ethanol, concentrate until each 5ml contains 1g ginseng medicinal materials, and obtain 40g ginseng extract; take Chuanxiong, crush , using water distillation to obtain 40g of Rhizoma Chuanxiong volatile oil; the above-mentioned extracts were mixed uniformly to prepare the active ingredient of the present invention.

[0051] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass it through a 200-mesh sieve, 60-65 wt% of which is put into the side spray pot of the fluidized bed as...

Embodiment 3

[0054] The preparation of the active ingredient of the present invention: take ginkgo biloba, add 5 times the amount of 65% ethanol, heat and reflux extraction twice, each time for 1 hour, the temperature is 60 ° C, combine the extracts, concentrate, pass through the macroporous adsorption resin (D101) for refining, Elute with 85% ethanol, concentrate the eluent to recover ethanol, and obtain 340 g of ginkgo leaf extract; take ginseng, ethanol, heat and reflux extraction 3 times, each time for 1 hour, combine the extracts, concentrate, and refine through neutral alumina. Elute with alcohol, concentrate the eluent to recover ethanol, obtain Ginkgo biloba extract, and obtain 20 g of Ginseng extract; take Rhizoma Chuanxiong, pulverize, and use water distillation to obtain 40 g of volatile oil of Rhizoma Chuanxiong; mix the above-mentioned extracts evenly to prepare the present invention. active ingredient.

[0055] Preparation of masterbatch: take a mixture of dextrin and starch ...

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Abstract

The invention provides a traditional Chinese medicine granular preparation with compound ginkgo biloba and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule of compound ginkgo biloba and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba L. Contains flavonoids (more than 20 kinds), terpenoids, phenols, beneficial trace elements and 17 kinds of amino acids and other active ingredients, which can reduce serum cholesterol, increase coronary blood flow, improve cerebral blood circulation, relieve smooth muscle spasm, relax bronchi and Antibacterial and other pharmacological effects. Clinically, it is not only used in the treatment of cardiovascular and cerebrovascular diseases, but also has good effects on the nervous system and respiratory system. Scientists such as France and Germany have confirmed that Ginkgo biloba extract has significant curative effects in the treatment of cerebral ischemia, sequ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K36/258A61K9/16A61K47/04A61K47/36A61K47/38A61K47/40A61P3/06A61P9/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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