Synergistic microbicidal compositions

A composition and mixture technology, which is applied in biocides, chemicals for biological control, animal repellants, etc., can solve the problems of inability to provide microbial control, poor microbial activity, etc.

Active Publication Date: 2009-07-01
NUTRITION & BIOSCIENCES USA 2 LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In some cases, even at high application concentrations, due to poor activity of commercially available microbicides against certain classes of microorganisms (e.g., m

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0055] Materials and methods

[0056] The synergy of the combinations of the invention is demonstrated by testing a wide range of compound concentrations and ratios.

[0057] A measure of synergy is Kull, F.C.; Eisman, P.C.; Sylwestrowicz, H.D. and Mayer, R.L. in Applied Microbiology (Applied Microbiology) 9: 538-541 (1961) proposed in the industry acceptable method, the method uses The ratio determined by:

[0058] Q a / Q A +Q b / Q B = Synergy Index ("SI")

[0059] In the formula:

[0060] Q A = Concentration of Compound A (first component) that produced the endpoint when used alone (MIC of Compound A), in ppm.

[0061] Q a = Concentration of compound A in ppm which produces the endpoint when used in mixture.

[0062] Q B= Concentration of Compound B (second component) that produced the endpoint when used alone (MIC of Compound B) in ppm.

[0063] Q b = Concentration of compound B in ppm which produces the endpoint when used in mixture.

[0064] When Q a / Q ...

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PUM

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Abstract

This invention relates to synergistic combinations of selected microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater efficacy than would be expected from combinations of the individual components. The combinations include mixtures of (a) 5-Chloro-2-methyl-4-isothiazolin-3-one+2-Methyl-4-isothiazolin-3-one, :(b) Methyl-4-isothiazolin-3-one, or (c) 1,2-Benzisothiazolin-3-one with one or more of a variety of other compounds.

Description

technical field [0001] The present invention relates to the synergistic combination of selected microbicides with other microbicides, formulation components, or raw materials, which synergistically combines to produce a composition having a microbicidal activity greater than that of the individual components The activity expected to be achieved by the combination. Background technique [0002] In some cases, even at high application concentrations, due to poor activity of commercially available microbicides against certain classes of microorganisms (e.g., microorganisms resistant to some microbicides), or due to severe environmental conditions, The commercially available microbicides mentioned above also do not provide effective microbial control. Combinations of different microbicides are sometimes used to provide overall control of microorganisms in a specific end-use environment. For example, U.S. Patent Application Publication No. 2004 / 0014799 discloses 2-methyl-4-isot...

Claims

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Application Information

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IPC IPC(8): A01N43/80A01N43/78A01N37/02A01N37/18A01P1/00
CPCA01N43/80A61P31/04A01N25/30A01N37/02A01N2300/00A01N29/00
Inventor M·A·戴尔D·A·肖
Owner NUTRITION & BIOSCIENCES USA 2 LLC
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