The invention belongs to the field of washing and care products and particularly discloses a liquid shampoo for effectively preventing pathological alopecia and a preparation method thereof. The liquid shampoo for effectively preventing the pathological alopecia is prepared from raw materials including collagen protein powder, ginger, ginseng, anredera cordifolia, cortex dictamni, saponin, cacumen biotae, cortex albiziae, black sesame seeds, humulus japonicus, bamboo salt, wild chrysanthemum flowers, radix polygonati officinalis, pomegranate peel, almond kernels, tangerine, alkyl glycoside, zinc pyrithione, hydroxypropyl methyl cellulose, an amino acid moisturizing agent, sodium dodecyl benzene sulfonate, lauroyl lysine, emulsified silicone oil, cocamidopropyl betaine, 5-Chloro-2-Methyl-4-Isothiazolin-3-One, nut oil, rosemary essential oil, jojoba oil and deionized water and is safe and non-irritant to the hair and scalp. In the liquid shampoo for effectively preventing pathological alopecia, a variety of raw materials are matched, the mutual synergic or resisting effect of the raw materials is utilized, the effects of nourishing and protecting hair and preventing hair loss are improved, scalp blood micro-circulation can be effectively promoted, and the metabolism of the scalp itself can be improved.