Osteoinductive calcium phosphates
A calcium phosphate, inductive technology, used in medical science, tissue regeneration, prosthesis, etc., can solve the problems of loss of structural integrity of remaining bone, limited autologous bone, etc., and achieve the effect of excellent osteoinductive behavior
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[0088] The preparation of the green body suitably comprises the formation of a calcium phosphate (CaP) slurry, wherein said CaP is suspended, preferably in powder form, in a solution comprising a blowing agent. Foaming agent (such as H 2 o 2 ) in the blowing agent solution is suitably in the range of 0.1% to 10.0%, and the solvent is suitably water. Blowing agent solution (such as H 2 o 2 , 0.1-10.0% aqueous solution) and calcium phosphate are mixed to form a slurry ratio suitably between 10-300ml blowing agent solution / per 100g CaP. The amount of porogen (eg naphthalene particles, 2 o 2 , it may be at 50-70°C), and then dried, for example, at 80-110°C to form a porous green body, which is then sintered and optionally ground to form the microparticles of the invention.
[0089] In order to prepare the osteoinductive material of the present invention, the calcium phosphate-based material is sintered under conditions such that an osteoinductive material as described above i...
Embodiment 1
[0113] Example 1 TCP particles with a size of 212-300 μm and a pore size of 0.5-1.5 μm
[0114] 1.1 Preparation of materials
[0115] Tricalcium Phosphate Ceramics
[0116] Mix TCP powder (Plasma Biotal, UK) with H 2 o 2 The solution (1.0-2.0% aqueous solution, 100-200ml / 100g TCP powder) and naphthalene particles (500-1400μm, 0-150g / 100g powder) were mixed and foamed at 50-70°C to obtain a porous green body. After drying and evaporating naphthalene at 80-110°C, the green body was sintered at 1100°C for 8 hours. Ceramic particles (1.0-3.0 mm) and microparticles (212-300 μm) were prepared and ultrasonically cleaned with acetone, ethanol and water, and finally dried at 80°C.
[0117] 1.2 Characterization of materials
[0118] The chemistry of the material was analyzed by XRD, and the micropores were analyzed by SEM (morphology) and mercury intrusion porosimetry (micropore size).
[0119] The results are shown in Figure 1-3 , and showed that the as-prepared material was che...
Embodiment 2
[0127] Example 2. Material Properties Affecting the Bone Formation Capability of Two Tricalcium Phosphate Ceramics
[0128] In this example, a comparison was made between two tricalcium phosphate ceramics with different grain sizes and micropore pore sizes and different protein absorption and bone formation capabilities in an osteoinductive research model (non-bone implant).
[0129] 2.1 Materials
[0130] According to the method of the present invention using H 2 o 2 A TCP ceramic (TCP-01) was prepared as blowing agent from irregularly shaped TCP powder with a D (v.0.5) size of 2.82 μm (Table 1). Briefly, TCP powder was mixed with diluted H 2 o 2 Solution (0.1-5.0%; typically 2% by weight) and naphthalene particles (commercially available particles from Sigma-Aldrich, optionally ground and sieved through a sieve with a mesh size of 1400 μm, the 2 o 2 slurry in solution. The slurry is then foamed by placing the slurry in an oven at 50-70°C (without stirring, usually over...
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