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Mixed gel for injection and preparation method thereof

A mixed gel and injection technology, which is applied in the field of medicine, can solve the problems of short retention time and easy diffusion, and achieve the effect of long maintenance time, good curative effect and good plasticity

Active Publication Date: 2012-07-25
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural HA is easily degraded by enzymes in body tissues, and its good water solubility makes it easy to diffuse in tissues, making its local retention time in animal tissues very short

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] References [Fang Li and Tan Tianwei, Chemical Reaction Engineering and Technology, 2003, 19 (4): 295-299] method to prepare PASP: take L-ASP as raw material, phosphoric acid as catalyst, sulfolane as solvent, and heat to 200 °C, reacted for 4.5h, and removed the generated water during the reaction. After the reaction is completed, the reaction product is repeatedly washed with methanol and water until neutral, and dried under reduced pressure at 40° C. to obtain a reaction intermediate polysuccinimide (PSI) with a molecular weight of about 400,000 to 500,000. Under the condition of ice bath, take PSI and add 5-6 times of 2mol / L NaOH solution to hydrolyze for 15min, then dropwise add methanol-NaCl saturated solution to form a precipitate, leave it overnight, filter, collect the precipitate and dry it under reduced pressure at 40°C to obtain PASP solid. Disperse PASP in deionized water, pass through an 80-mesh sieve, and add an equal volume of 2-fold isotonic phosphate b...

Embodiment 2

[0044] Reference method (CN1814650) to prepare PASP resin: prepare PSI according to the method described in Example 1, crush PSI, pass through a 160-mesh sieve, add 30 times deionized water, continue stirring for 8-10 hours, and add cross-linking agent hexamethylenediamine at intervals When the concentration reaches 0.5%, add 3 to 4 times of ethanol after the stirring is completed, let it stand for 3 days, collect the precipitate and dry it under reduced pressure at 25°C, crush the dried product, pass through a 160-mesh sieve, add 20 times of 50% ethanol solution, and stir for 30 minutes. Add 20% NaOH solution dropwise to the reaction solution until the reaction liquid is in a colloidal state, add 3 to 5 times of ethanol, place it for 3 days, collect the precipitate, wash and purify it with ethanol and deionized water alternately for several times, finally collect the precipitate from ethanol, and reduce it at 40°C Press and dry to obtain PASP resin. Disperse the PASP resin in...

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Abstract

The invention relates to a mixed gel applied to injection and a preparation method thereof. The mixed gel of the invention is characterized by comprising polyaspartic acid terpenoid gel particle, cross bonding hyaluronic acid gel particle and hyaluronic acid or salt solution thereof, wherein, the volume of the polyaspartic acid terpenoid gel particle accounts for 5-80%, the volume ratio of the cross bonding hyaluronic acid gel particle and hyaluronic acid or salt solution thereof ranges from 1:19-19:1; the preparation method of the mixed gel has the following steps: respectively preparing thepolyaspartic acid terpenoid gel particle and cross bonding hyaluronic acid gel particle; mixing evenly the particles with hyaluronic acid dissolved in the isosmotic solution after full swelling and balancing in isosmotic solution, sterilizing and packaging the mixture to obtain the finished product. The mixed gel of the invention can be used to prepare injection for beauty care and medical treatment and has the characteristics of long hold time and little side effect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a mixed gel for injection and a preparation method thereof. The mixed gel is composed of polyaspartic acid compound gel particles, cross-linked hyaluronic acid gel particles and hyaluronic acid or its salt solution, and can be used for skin soft tissue and intra-articular injection. Background technique [0002] There are many types of polyaspartic acid compounds, and the current research and application are more widely used polyaspartic acid (polyaspartic acid, PASP) or its salt, polyaspartamide (polyaspartamide, PASPA) or its derivatives, polyaspartic acid Copolymers, etc., are a new generation of degradable biopolymer materials. Natural PASP exists in the shells of mollusks and snails, and the relative molecular mass ranges from 1000 to hundreds of thousands. PASP is a polycarboxylic acid with amino groups. In addition to the characteristics of general polycarboxylic acid, it also has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04
Inventor 凌沛学陈建英贺艳丽税庆华刘杰汪敏荣晓花
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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