Amphiphilic superparamagnetism magnetic resonance contrast medium

Abstract

The invention discloses an amphiphilic superparamagnetism magnetic resonance contrast medium and a preparation method thereof. The contrast medium takes MnFe2O4 nanometer grains as cores; polyalcohol The invention discloses an amphiphilic superparamagnetism magnetic resonance contrast medium and a preparation method thereof. The contrast medium takes MnFe2O4 nanometer grains as cores; polyalcoholmical compatibility, low toxicity and good stability. The preparation method has the advantages of simple operation, low cost, low requirements on the equipment, and easy realization of industrialiological compatibility, low toxicity and good stability. The preparation method has the advantages of simple operation, low cost, low requirements on the equipment, and easy realization of industrialized production.ized production.olecules evenly clad the surfaces of the MnFe2O4 nanometer grains; and part of hydroxies on the outer ends of the polyalcohol molecules react with 9-fluorenylmethyl chloroformate to form amphiphilicmolecules evenly clad the surfaces of the MnFe2O4 nanometer grains; and part of hydroxies on the outer ends of the polyalcohol molecules react with 9-fluorenylmethyl chloroformate to form amphiphilicshell structures through acyl chloride reactions. The preparation method comprises the following steps: taking the polyalcohol as a solvent, pyrolyzing ferric and manganese acetylacetonates at a highshell structures through acyl chloride reactions. The preparation method comprises the following steps: taking the polyalcohol as a solvent, pyrolyzing ferric and manganese acetylacetonates at a hightemperature to obtain the MnFe2O4 nanometer grains clad by the polyalcohol molecules through, and then carrying out the acyl chloride reaction between 9-fluorenylmethyl chloroformate and polyalcohol htemperature to obtain the MnFe2O4 nanometer grains clad by the polyalcohol molecules through, and then carrying out the acyl chloride reaction between 9-fluorenylmethyl chloroformate and polyalcohol hydroxies on the surfaces of the nanometer grains. The contrast medium has the advantages of small grain size, high crystallinity, high saturation magnetization rate, high relaxation capability, good bydroxies on the surfaces of the nanometer grains. The contrast medium has the advantages of small grain size, high crystallinity, high saturation magnetization rate, high relaxation capability, good biolog

Description

An amphiphilic superparamagnetic magnetic resonance contrast agent technical field The invention relates to a superparamagnetic magnetic resonance contrast agent, in particular to an amphiphilic shell structure with MnFe2O4 nanoparticles as the core, which has a hydrophilic and lipophilic amphiphilic shell structure, and has a simple preparation process, low manufacturing cost, and Industrialized implementation of superparamagnetic magnetic resonance contrast agents. Background technique Magnetic Resonance Imaging (MRI) is the most important advanced medical imaging technology developed after the 1980s. It has outstanding advantages such as high resolution, multiple imaging parameters, and safe use. It has great potential in medical diagnosis and basic research. Huge application potential. MRI contrast agent is an imaging-enhanced contrast agent used to shorten imaging time and improve imaging contrast and clarity. It can change the relaxation rate of water protons in loc...

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Problems solved by technology

However, studies have shown that the magnetic moment and R2 coefficient of ferric oxide nanomaterials are very low, which is not suitable for advanced magnetic resonance imaging applications.

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