Hydroxyapatite powder with upconversion fluorescence and superparamagnetism and preparation method thereof

A technology of hydroxyapatite and superparamagnetism, which is applied in the fields of biomedical materials and biomedical engineering, can solve the problems of non-fluorescence characteristics, inability to realize material distribution and bone formation process, bone tissue regeneration and reconstruction, and achieve fluorescence High intensity, avoid tissue autofluorescence interference, and promote bone formation

Active Publication Date: 2020-09-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But since the composite is a HA-wrapped Fe 3 o 4 Although the core-shell powder can achieve bone bonding with bone tissue through the surface HA layer in vivo, its Fe 3 o 4 The ingredients are wrapped in the HA layer. As a foreign matrix different from bone minerals, it will reside in the body for a long time, which will affect the regeneration and reconstruction of bone tissue.
Furthermore, whether it is Fe-doped HA or superparamagnetic Fe wrapped by HA 3 o 4 Although the prepared composite materials can promote cell proliferation and osteogenesis under the action of an external magnetic field, they do not have fluorescence properties, and it is impossible to trace the material through fluorescence, especially the up-conversion fluorescence that is not interfered by tissue autofluorescence. The distribution and bone formation process in the body, and the presence of iron ions will quench the fluorescence and luminescence intensity of rare earth ions

Method used

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  • Hydroxyapatite powder with upconversion fluorescence and superparamagnetism and preparation method thereof
  • Hydroxyapatite powder with upconversion fluorescence and superparamagnetism and preparation method thereof
  • Hydroxyapatite powder with upconversion fluorescence and superparamagnetism and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The steps for preparing HA:Yb+Ho / 0.25Fe powder in this example are as follows:

[0036] (1) In a 50mL hydrothermal reaction kettle, add 0.5g octadecylamine and 4mL oleic acid into 16mL ethanol, mix well to obtain an alcohol solution containing octadecylamine and oleic acid, then add 9mL calcium nitrate aqueous solution (Ca 2+ molar concentration is 0.2mol / L) to obtain the first mixed solution, in the first mixed solution, add 2mL Yb (NO 3 ) 3 Aqueous solution [contains Yb(NO 3 ) 3 0.36mmol] and 2mL Ho(NO 3 ) 3 Aqueous solution [contains Ho(NO 3 ) 3 0.036mmol] to obtain the mixed solution, at 70°C, under stirring conditions, 9mL sodium phosphate aqueous solution (PO 4 3- The molar concentration is 0.12mol / L) is added dropwise in the second mixed solution of gained, during the dropping process, by adding ammonia water, the pH value of the reaction system is maintained at 10, and then the resulting suspension is packed into the hydrothermal reaction kettle after ...

Embodiment 2

[0039] The steps of preparing HA:Yb+Ho / 0.5Fe powder in this embodiment are as follows:

[0040] (1) In a 50mL hydrothermal reaction kettle, add 0.5g octadecylamine and 4mL oleic acid into 16mL ethanol, mix well to obtain an alcohol solution containing octadecylamine and oleic acid, then add 9mL calcium nitrate aqueous solution (Ca 2+ molar concentration is 0.2mol / L) to obtain the first mixed solution, in the first mixed solution, add 2mL Yb (NO 3 ) 3 Aqueous solution [contains Yb(NO 3 ) 3 0.36mmol] and 2mL Ho(NO 3 ) 3 Aqueous solution [contains Ho(NO 3 ) 3 0.036mmol] to obtain the mixed solution, at 50 °C under stirring conditions, 9mL sodium phosphate aqueous solution (PO 4 3- The molar concentration is 0.12mol / L) is added dropwise in the second mixed solution of the gained, during the dropping process, the pH value of the reaction system is maintained at 9 by adding ammonia water, and then the resulting suspension is packed into the hydrothermal reaction kettle aft...

Embodiment 3

[0043] The steps of preparing HA:Yb+Ho / 1Fe powder in this embodiment are as follows:

[0044] (1) In a 50mL hydrothermal reaction kettle, add 0.5g octadecylamine and 4mL oleic acid into 16mL ethanol, mix well to obtain an alcohol solution containing octadecylamine and oleic acid, then add 9mL calcium nitrate aqueous solution (Ca 2+ molar concentration is 0.2mol / L) to obtain the first mixed solution, in the first mixed solution, add 2mL Yb (NO 3 ) 3 Aqueous solution [contains Yb(NO 3 ) 3 0.36mmol] and 2mL Ho(NO 3 ) 3 Aqueous solution [contains Ho(NO 3 ) 3 0.036mmol] to obtain the mixed solution, at 50 °C under stirring conditions, 9mL sodium phosphate aqueous solution (PO 4 3- The molar concentration is 0.12mol / L) is added dropwise in the second mixed solution of gained, during the dropping process, by adding ammonia water, the pH value of the reaction system is maintained at 10, and then the resulting suspension is packed into the hydrothermal reaction kettle after t...

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PUM

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Abstract

The invention discloses hydroxyapatite powder with up-conversion fluorescence and superparamagnetism and a preparation method thereof. The preparation method adopts a step-by-step hydrothermal synthesis technology and specifically comprises the following steps: step 1, preparing hydroxyapatite powder HA:Ln1+Ln2 rich in two or more rare earth ions and up-conversion fluorescence with adjustable luminous color by hydrothermal synthesis; and step 2, performing hydrothermal reaction to realize exchange between iron ions and HA crystal surface cations (Ca<2+> and / or Ln<3+>) so as to obtain HA:Ln1+Ln2 / Fe powder with superparamagnetism. The obtained hydroxyapatite powder has high up-conversion fluorescence intensity and strong penetrability under the excitation of near infrared light and can avoidtissue autofluorescence interference; and furthermore, the obtained hydroxyapatite powder has superparamagnetism under the action of an external magnetic field, thereby being favorable for promotingcell proliferation and osteogenesis. The hydroxyapatite powder has wide application prospects in the aspects of biomedicine fundamental research, development of high-performance bone and tooth repairmaterials, osteogenesis promotion, in vivo tracing research of biological materials, and the like.

Description

technical field [0001] The invention belongs to the technical fields of biomedical materials and biomedical engineering, and relates to an apatite powder with upconversion fluorescence and superparamagnetism and a preparation method thereof. Background technique [0002] Bone and tooth repair materials have always been a hot spot in the research of biomedical materials. Synthetic hydroxyapatite (Hydroxyapatite, HA) crystals have similar composition and crystal structure to human bone and tooth inorganic substances, so they have good effects on cells and tissues. Affinity, can achieve better bone bonding with new bone tissue, and can be used as bone and tooth restoration materials. However, how to further improve the osteogenic performance of HA and effectively trace the osteogenic process of HA in vivo is still a technical and clinical problem to be solved. [0003] In order to further improve the osteogenic properties of HA, the prior art discloses the introduction of Fe i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/71H01F1/01A61L27/12A61L27/50
CPCA61L27/12A61L27/50A61L2430/02A61L2430/12C09K11/7778H01F1/0018H01F1/01
Inventor 李西宇李伟
Owner SICHUAN UNIV
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