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Aqueous antiseptic solution and compatible anionic dye for staining skin

A technology of anionic dyes and aqueous solutions, applied in the field of cationic dyes, can solve the problem of uneven distribution of colored solutions

Inactive Publication Date: 2009-09-02
ALLEGIANCE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another problem is that the colorant can leach out of solution, resulting in an uneven distribution of the colored solution upon application

Method used

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  • Aqueous antiseptic solution and compatible anionic dye for staining skin
  • Aqueous antiseptic solution and compatible anionic dye for staining skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The compatibility of anionic dyes alone with aqueous CHG (ie without addition of cationic excipients) was tested. A 0.13% w / v anionic dye solution was prepared by dissolving 0.13g FD&C Yellow 6 in 100ml distilled water. 20% w / v CHG in water was then added dropwise to the dye solution. After adding two drops of aqueous CHG to the dye solution, a precipitate formed, demonstrating the incompatibility of the dye alone with aqueous CHG.

Embodiment 2

[0037] To test the compatibility of anionic dyes and cationic excipients, various solutions were prepared with different anionic dyes and cationic excipients. The cationic excipients tested included: CPC, cetyltrimethylammonium bromide, benzethonium chloride and benzalkonium chloride. The anionic dyes tested included: FD&C Green No. 3 (Fast Green FCF), FD&C Yellow No. 5 (Tartrazine), FD&C Red No. 40 (Brilliant Red), FD&C Yellow No. 6 (Sunset Yellow FCF), FD&C Blue No. 1 (Vivid Blue FCF), FD&C Blue No. 2 (Indigo Carmine), and FD&C Red No. 3 (erythrosine). The chemical structures and chemical classes of the various pigments mentioned above are shown below.

[0038]

[0039] Chemical Name: FD&C Green No. 3 Chemical Name: FD&C Yellow No. 5

[0040] Chemical class: Triaryl methane Chemical class: Azo

[0041]

[0042] Chemical Name: FD&C Red No. 40 Chemical Name: FD&C Yellow No. 6

[0043] Chemical Class: Azo Chemical Class: Azo

[0044]

[0045] Chemical Name: ...

Embodiment 3

[0052] A titration experiment was designed to determine the appropriate molar ratio of cationic excipient to anionic dye. Experiments were performed using CPC as cationic excipient and FD&C Yellow No. 6 as dye. Place a known volume of 4mM CPC solution in a beaker and titrate 2% w / v FD&C Yellow No. 6 solution for titration experiment. A solution containing CPC and FD&C Yellow No. 6 was added dropwise to 2.0% w / v CHG in water. The results show that the minimum molar ratio of CPC to FD&C Yellow No. 6 is about 2:1. This result represents the charge ratio between the two components.

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PUM

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Abstract

Aqueous antiseptic solutions and compatible dyes and methods for making and using such solutions are provided. More specifically, in one embodiment, the present invention relates to an aqueous antiseptic solution comprising an aqueous solution of chlorhexidine or a salt thereof, an anionic dye in an amount sufficient to stain a patient's skin when the aqueous solution is applied thereon, and a cationic excipient.

Description

Background technique [0001] Antisepsis is the destruction or inhibition of microorganisms present on living tissue. Disinfectants kill microorganisms or inhibit their growth. Commonly used disinfectants include iodine, boric acid, and alcohol. Another type of disinfectant used is chlorhexidine, including its salts, such as chlorhexidine gluconate (CHG). CHG is a particularly effective disinfectant, exhibiting a strong affinity for the skin, high antimicrobial activity and a prolonged residual effect. CHG has been found to be a fast-acting, long-lasting and excellent preoperative skin preparation that kills more bacteria than conventional iodophors or alcohols. Moreover, CHG is rapidly active against both Gram-positive and Gram-negative bacteria. [0002] Alcohols such as isopropanol are often used as solvents for CHG solutions. Examples of alcohol based CHG solutions are , a solution of 2% w / v CHG in 70% v / v isopropanol, available from Medi-Flex, Inc., Leawood (Kansas)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02
CPCA61K31/655A61K31/155A61P31/02
Inventor 安杰尔·G·马加隆凯尔·W·布恩詹姆士·R·巴德韦尔
Owner ALLEGIANCE CORP
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