Method for preparing compound biological activity sterilizing fluid
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A technology of biological activity and disinfectant, applied in botany equipment and methods, chemicals for biological control, disinfectants, etc., can solve the problem of increasing skin and mucous membrane irritation, decreasing the stability of active iodine, affecting the sterilization and disinfection effect, etc. Problems, to achieve water-soluble broad-spectrum bactericidal effect, improve coordination and complexation, and good biocompatibility
Inactive Publication Date: 2011-06-08
山东贝诺医药生物科技有限公司
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However, the original micellar force of this kind of products with surfactant as the carrier will be destroyed after dilution, so that the stability of active iodine will decrease, and the concentration of free iodine will increase, which not only affects its sterilization and disinfection effect, but also increases the effect on skin and mucous membranes. the irritation of
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Embodiment 1
[0019] Get 0.5g low-molecular-weight chitosan and be dissolved in 60ml concentration and be in the 0.2% glacial acetic acid aqueous solution, add 5g didodecyl bis-quaternary ammonium salt under the condition of stirring, as 1 liquid, mix 2g povidone-iodine in 35ml Swell in water as 2 liquids, mix 1 liquid and 2 liquids evenly, add sodium hydroxide test solution to adjust the pH value to 4.5.
Embodiment 2
[0021] Get 1.0g low-molecular-weight chitosan and be dissolved in 70ml concentration and be 0.2% in the glacial acetic acid aqueous solution, add 4g didodecyl bis-quaternary ammonium salt under the condition of stirring, as 1 liquid, 1g povidone-iodine is in 25ml Swell in water as 2 liquids, mix 1 liquid and 2 liquids evenly, add sodium hydroxide test solution to adjust the pH value to 3.1.
Embodiment 3
[0023] Get 1.5g low-molecular chitosan quaternary ammonium salt and be dissolved in 70ml water, add 3.5g didodecyl diquaternary ammonium salt under the condition of stirring, as 1 liquid, 0.5g povidone iodine is swollen in 25ml water as 2 liquids, mix 1 liquid and 2 liquids evenly, add triethanolamine to adjust the pH value to 6.0.
[0024] Low-molecular chitosan quaternary ammonium salt or low-molecular chitosan solution of the present invention has following general formula:
[0025]
[0026] where R 1 , R 2 is a hydrocarbon group, R 1 The general formula is C n h 2n (n=1, 2, 3, 4, 5...), R 2 The general formula is C n h 2n+1 (n=1, 2, 3, 4, 5...).
[0027] Povidone-iodine of the present invention has following general formula:
[0028]
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Abstract
The invention discloses a method for preparing compound biological activity sterilizing fluid, which comprises the steps: a proper amount of surface active agent is added to low molecular chitosan quaternary ammonium salt or low molecular chitosan solution under a stirring condition to be used as first fluid, povidone iodine is swelled to be used as second fluid, and the first fluid and the second fluid are evenly mixed according to a proper proportion and are regulated to a prescriptive range by a chemical reagent to obtain the compound biological activity sterilizing fluid. The prepared compound biological activity sterilizing fluid uses low molecular chitosan and povidone as double carriers, the chitosan not only can strengthen the bacterium inhibiting and sterilizing effects of the povidone iodine, but also has a certain adsorbing function for iodine released by the povidone iodine, causes the release of the iodine to be doubly controlled to reduce the volatilization of the iodineand increase the release uniformity of the iodine, the chitosan has degradability, the skin mucosa protecting function and the bacterium inhibiting function, therefore, the compound biological activity sterilizing fluid is stable and environmental-friendly and has high efficiency, low toxicity, low irritation and the skin protecting function.
Description
technical field [0001] The invention relates to a disinfectant, in particular to a method for preparing a compound biologically active disinfectant. Background technique [0002] Povidone-iodine is the complex compound of iodine and polyvinylpyrrolidone (PVP), because it has advantages such as film-forming, adhesion, detoxification, slow release, strong water solubility and broad-spectrum bactericidal action ("Chinese Pharmacopoeia" 2005 edition, Clinical medication instructions. 2001.911), povidone-iodine has been more and more widely used in the sterilization and disinfection of skin and mucous membranes, operations and instruments. However, the original micellar force of this kind of products with surfactant as carrier will be destroyed after dilution, so that the stability of active iodine will decrease, and the concentration of free iodine will increase, which not only affects its sterilization and disinfection effect, but also increases the effect on skin and mucous me...
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