Novel method for synthesizing dyclonine hydrochloride
A technology of dyclonine hydrochloride and its synthesis method, which is applied in the direction of organic chemistry to achieve the effect of improving product yield, facilitating industrial production, and good quality
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Embodiment 1
[0049] (1) Synthesis of phenbutyl ether
[0050] Add 48Kg (510mol) of phenol and 84Kg of 30% sodium hydroxide solution into 45Kg of water, add 80Kg of bromobutane (584mol), react at 80°C for 10 hours, let the water layer stand, and wash the oil layer with water until neutral After vacuum distillation, 65.7Kg of phenbutyl ether was obtained with a yield of 85.8% and a content of 98.3%.
[0051] (2) Synthesis of p-butoxyacetophenone
[0052] Add 54Kg (360mol) of phenbutyl ether and 3.6Kg of zinc chloride (28mol) into 54Kg (529mol) of acetic anhydride, reflux for 4 hours, wash with water and sodium carbonate solution, then wash with salt water until neutral, and depressurize After distillation, 58.7Kg of p-butoxyacetophenone was obtained, the yield was 84.9%, and the content was 98.1%.
[0053] (3) Synthesis of Dyclonine Hydrochloride
[0054] Add 40Kg (208mol) p-butoxyacetophenone and 25.6Kg (210mol) piperidine hydrochloride into absolute ethanol, stir, then add 12Kg paraform...
Embodiment 2
[0056] In step (1), the reaction temperature is 100°C, and the weight of phenbutyl ether obtained is 66.3Kg, and the yield is 86.6%. Other steps are with embodiment 1.
Embodiment 3
[0058] In step (1), 45Kg of phenol and 67.5Kg of water were added (the weight ratio was 1:1.5), to obtain 66.7Kg of phenbutyl ether with a yield of 87.0%. Other steps are with embodiment 1.
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